Chhatwal Jasmeer P, Ressler Kerry J
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA.
CNS Spectr. 2007 Mar;12(3):211-20. doi: 10.1017/s1092852900020939.
The last decade has witnessed remarkable progress in the understanding of the mammalian cannabinoid system, from the cloning of the endogenous cannabinoid receptor to the discovery of new pharmacologic compounds acting on this receptor. Current and planned studies in humans include compounds with effects ranging from direct antagonists to inhibitors of reuptake and breakdown. This progress has been accompanied by a much greater understanding of the role of the cannabinoid system in modulating the neural circuitry that mediates anxiety and fear responses. This review focuses on the neural circuitry and pharmacology of the cannabinoid system as it relates to the acquisition, expression, and extinction of conditioned fear as a model of human anxiety. Preclinical studies suggest that these may provide important emerging targets for new treatments of anxiety disorders.
在过去十年中，我们对哺乳动物大麻素系统的认识取得了显著进展，从内源性大麻素受体的克隆到作用于该受体的新药理化合物的发现。目前以及计划开展的人体研究涵盖了各种化合物，其作用范围从直接拮抗剂到再摄取和分解抑制剂。与此同时，我们对大麻素系统在调节介导焦虑和恐惧反应的神经回路中所起的作用也有了更深入的了解。本综述聚焦于大麻素系统的神经回路和药理学，因为它与作为人类焦虑模型的条件性恐惧的习得、表达和消退有关。临床前研究表明，这些可能为焦虑症的新治疗方法提供重要的新兴靶点。
