Dilts P V, Hopkins M P, Chang A E, Cody R L
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor 48109-0718.
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):167-8. doi: 10.1016/0002-9378(92)91854-4.
A 49-year-old patient with breast cancer had a leiomyoma that rapidly enlarged shortly after she started therapy with tamoxifen. Exploratory laparotomy was necessary to confirm the diagnosis. The rapid growth may have resulted from the estrogen agonist properties of tamoxifen or alternatively by ovarian stimulation resulting in endogenous estrogen production.
一名49岁的乳腺癌患者在开始服用他莫昔芬治疗后不久，其平滑肌瘤迅速增大。需要进行剖腹探查术以确诊。肌瘤的快速生长可能是由于他莫昔芬的雌激素激动剂特性，或者是由于卵巢受到刺激导致内源性雌激素产生所致。
