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信号转导和转录激活因子3信号通路对转移的调控：临床意义

Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications.

作者信息

Huang Suyun

机构信息

Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA.

出版信息

Clin Cancer Res. 2007 Mar 1;13(5):1362-6. doi: 10.1158/1078-0432.CCR-06-2313.

DOI:10.1158/1078-0432.CCR-06-2313
PMID:17332277
Abstract

Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as one of the common pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes a potential preventive and therapeutic target for cancer metastasis.

摘要

众多细胞因子、生长因子和致癌蛋白可激活信号转导子和转录激活子3（Stat3），该蛋白已被公认为癌细胞中的常见信号通路之一。Stat3信号传导影响多种对细胞存活、增殖、侵袭、血管生成和免疫逃逸至关重要的基因的表达和功能。显然，Stat3信号通路调节癌症转移，并构成癌症转移的潜在预防和治疗靶点。

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