Chang John T, Palanivel Vikram R, Kinjyo Ichiko, Schambach Felix, Intlekofer Andrew M, Banerjee Arnob, Longworth Sarah A, Vinup Kristine E, Mrass Paul, Oliaro Jane, Killeen Nigel, Orange Jordan S, Russell Sarah M, Weninger Wolfgang, Reiner Steven L
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Science. 2007 Mar 23;315(5819):1687-91. doi: 10.1126/science.1139393. Epub 2007 Mar 1.
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.
哺乳动物免疫的一个标志是经历过病原体的淋巴细胞之间存在细胞命运的异质性。我们发现，最初对微生物作出反应的正在分裂的T淋巴细胞，会对介导信号传导、细胞命运决定和不对称细胞分裂的蛋白质进行不平等分配。在分裂前，T细胞与其抗原呈递细胞之间的长时间相互作用似乎协调了决定因素的不对称分离。此外，最初的两个子代T细胞表现出在效应细胞谱系和记忆细胞谱系中命运不同的表型和功能指标。这些结果提示了一种机制，通过该机制单个淋巴细胞可以分配适应性免疫所需的多种细胞命运。
