Hohenberger W, Merkel S, Weber K
Chirurgische Klinik, Universität Erlangen-Nürnberg, Krankenhausstrasse 12, 91054 Erlangen.
Chirurg. 2007 Mar;78(3):217-25. doi: 10.1007/s00104-007-1311-y.
For advanced adenocarcinomas, which are the most frequent tumours of the lower GI tract, the concept of radical lymphnode dissection is well accepted. The quality of lymphadenectomy for these malignancies has a strong effect on cancer-related survival. Based upon a strict quality control program with outcome evaluated according to internal results, the technique and extent of lymph node dissection have been continuously developed over the last three decades. These are described in detail, including instructive pictures to clarify the surgical steps needed. Apart from multivisceral resection in far advanced cases, which still have a chance of cure if adequate guidelines are followed, two additional steps in the so-called radical surgical treatment of these tumours are prerequisites for cure. The first is complete mobilisation of the intestine involving complete mesocolic excision with complete retention of the visceral fascia and covering potential lymph node metastases and extranodal spread on the intestinal side. The second step is the central tying of the tumor's supplying vessels. Following these rules and with no adjuvant systemic treatment, 5-year survival figures of 80% can be reached, even for UICC stage III disease.
对于晚期腺癌(下消化道最常见的肿瘤),根治性淋巴结清扫的概念已被广泛接受。这些恶性肿瘤的淋巴结切除术质量对癌症相关生存率有很大影响。基于严格的质量控制计划,并根据内部结果评估预后,在过去三十年中,淋巴结清扫的技术和范围不断发展。文中对这些内容进行了详细描述,包括用于阐明所需手术步骤的指导性图片。除了在极晚期病例中进行多脏器切除(如果遵循适当的指导原则仍有治愈机会)外,在这些肿瘤的所谓根治性手术治疗中,还有另外两个步骤是治愈的先决条件。第一步是完全游离肠道,包括完整的结肠系膜切除,同时完全保留脏层筋膜,覆盖潜在的淋巴结转移和肠侧的结外扩散。第二步是在肿瘤供血血管的中心进行结扎。遵循这些规则且不进行辅助全身治疗,即使是国际抗癌联盟(UICC)III期疾病,5年生存率也能达到80%。