Lima Virgília Luna Castor de, Rangel Osias, Andrade Valmir Roberto, Silveira Naoko Yanagizawa Jardim da, Oliveira Susely Salviano de, Figueiredo Luiz Tadeu M
Superintendencia de Controle de Endemias, Rua Sao Carlos 546, Campinas, SP 13035-420, Brazil.
Cad Saude Publica. 2007 Mar;23(3):669-80. doi: 10.1590/s0102-311x2007000300025.
The epidemiology of dengue in the municipality of Campinas, São Paulo, Brazil, was studied in 1998 using a randomized sero-epidemiological survey. Epidemiological surveillance data from 1996-2003 were also analyzed, with an emphasis on virological surveillance. 1,260 individuals participated in the survey and had blood samples drawn by finger stick on filter paper. Blood samples were tested by EIA-ICC, an enzyme immunoassay using infected cells as antigen. Dengue antibody prevalence (14.79%) was lower than in other surveys in other States of Brazil, but higher than in two other serological surveys in São Paulo State. Dengue antibody prevalence was far higher than the reported case incidence during the 1996, 1997, and 1998 epidemics. Antibody prevalence and reported case incidence in different health districts were disproportional. The article concludes by recommending further research on the significance of transmission rates during epidemics and more intensive virological surveillance, especially in years with few reported cases.
1998年，巴西圣保罗州坎皮纳斯市运用随机血清流行病学调查方法对登革热的流行病学情况展开了研究。同时还分析了1996年至2003年的流行病学监测数据，重点是病毒学监测。1260人参与了此次调查，通过手指采血将血样采集到滤纸上。血样采用EIA - ICC检测，这是一种以感染细胞为抗原的酶免疫测定法。登革热抗体流行率（14.79%）低于巴西其他州的其他调查，但高于圣保罗州的另外两项血清学调查。登革热抗体流行率远高于1996年、1997年和1998年疫情期间报告的病例发病率。不同卫生区的抗体流行率和报告病例发病率不成比例。文章最后建议进一步研究疫情期间传播率的意义，并加强病毒学监测，尤其是在报告病例较少的年份。
