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在对人上皮细胞和前列腺癌细胞进行的体外细胞毒性试验中确定的特定玛咖表型（）与锯棕榈（）提取物联合用于前列腺癌化学预防的协同作用。

Synergism of Specific Maca Phenotypes () in Combination with Saw Palmetto () Extract for Chemoprevention of Prostate Cancer as Determined in In Vitro Cytotoxicity Assays on Human Epithelial and Prostate Cancer Cells.

作者信息

Gaweł-Bęben Katarzyna, Kukula-Koch Wirginia, Szwajgier Dominik, Antosiewicz-Klimczak Beata, Orihuela-Campos Rita Cristina, Głowniak Kazimierz, Meissner Henry O

机构信息

Department of Cosmetology, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.

Department of Pharmacognosy with Garden of Medicinal Plants, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.

出版信息

Molecules. 2024 Nov 28;29(23):5632. doi: 10.3390/molecules29235632.

DOI:10.3390/molecules29235632
PMID:39683791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643235/
Abstract

Selected phenotypes of dried maca () hypocotyls and supercritical CO extract (USPlus) of saw palmetto () were used to determine their targeted, cytotoxic action in prostate cancer cells. Fingerprinting by HPLC-MS and PCA analysis showed compositional differences in glucosinolates, amides, macamides, and other alkaloids, which varied based on the color and the size of hypocotyls. These phytochemical differences translated into a higher antioxidant potential of red maca than black maca samples. The greatest COX-2 inhibition was demonstrated with a combination of red maca: saw palmetto (67%:33%) and red maca: saw palmetto: black maca (25%:50%:25%). The LNCaP androgen-dependent prostate cancer cell line was the most sensitive to the three-component mixture of black, red maca, and saw palmetto treatment. This combination provided the most abundant set of high-activity metabolites, and is worthy of consideration in further clinical applications and future in-depth study.

摘要

选用玛咖（）干燥下胚轴和锯叶棕（）超临界CO提取物（USPlus）的特定表型，以确定它们对前列腺癌细胞的靶向细胞毒性作用。通过HPLC-MS指纹图谱和主成分分析显示，芥子油苷、酰胺、玛卡酰胺和其他生物碱的成分存在差异，这些差异因下胚轴的颜色和大小而异。这些植物化学差异导致红玛咖比黑玛咖样品具有更高的抗氧化潜力。红玛咖与锯叶棕（67%:33%）以及红玛咖、锯叶棕与黑玛咖（25%:50%:25%）的组合表现出最大的COX-2抑制作用。LNCaP雄激素依赖性前列腺癌细胞系对黑玛咖、红玛咖和锯叶棕的三组分混合物治疗最为敏感。这种组合提供了最丰富的高活性代谢物组，值得在进一步的临床应用和未来深入研究中加以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/bc36323a3dc8/molecules-29-05632-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/b47bf083026a/molecules-29-05632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/bffed99acee4/molecules-29-05632-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/a23c5540ffd4/molecules-29-05632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/83c13c89157b/molecules-29-05632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/06bf8e330946/molecules-29-05632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/ee63deba0c3c/molecules-29-05632-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/d8eab37ec648/molecules-29-05632-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/3c21f632609a/molecules-29-05632-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/bc36323a3dc8/molecules-29-05632-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/b47bf083026a/molecules-29-05632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/bffed99acee4/molecules-29-05632-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/a23c5540ffd4/molecules-29-05632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/83c13c89157b/molecules-29-05632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/06bf8e330946/molecules-29-05632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/ee63deba0c3c/molecules-29-05632-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/d8eab37ec648/molecules-29-05632-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/3c21f632609a/molecules-29-05632-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11643235/bc36323a3dc8/molecules-29-05632-g009.jpg

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The Distribution of Glucosinolates in Different Phenotypes of and Their Role as Acetyl- and Butyrylcholinesterase Inhibitors-In Silico and In Vitro Studies.不同表型芜菁中的硫代葡萄糖苷分布及其作为乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂的作用： 体内和体外研究。
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Treatment of Benign Prostatic Hyperplasia by Natural Drugs.
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