Jinlian Li, Yingbin Zhou, Chunbo Wang
Medical College, Qingdao University, 422 Room, Boya Building, 308 Ningxia Road, Qingdao, 266071, China.
J Biomed Sci. 2007 May;14(3):303-12. doi: 10.1007/s11373-007-9148-4. Epub 2007 Mar 3.
Solar ultraviolet (UV) radiation is a major environmental factor that causes DNA damage, inflammation, erythema, sunburn, immunosuppression, photoaging, gene mutations, and skin cancer. p38 mitogen activated protein kinase (MAPK) are strongly activated by UV radiation, and play important roles in regulating cellular responses to UV. In this review, we examine the role played by p38 MAPK in mediating UV-induced cell cycle, apoptosis, inflammation, and skin tanning response. We review the role played by p38 MAPK in transcriptional regulation of key downstream genes that have been implicated in the regulation of cellular responses to UV radiation. Understanding this will undoubtedly help in the prevention and control of UV-induced damage and the development of novel therapeutic strategies.
太阳紫外线（UV）辐射是导致DNA损伤、炎症、红斑、晒伤、免疫抑制、光老化、基因突变和皮肤癌的主要环境因素。p38丝裂原活化蛋白激酶（MAPK）被紫外线辐射强烈激活，并在调节细胞对紫外线的反应中发挥重要作用。在本综述中，我们研究了p38 MAPK在介导紫外线诱导的细胞周期、凋亡、炎症和皮肤晒黑反应中所起的作用。我们回顾了p38 MAPK在关键下游基因转录调控中的作用，这些基因与细胞对紫外线辐射反应的调节有关。了解这一点无疑将有助于预防和控制紫外线诱导的损伤以及开发新的治疗策略。
