Morita Shigeaki, Tanaka Masaru, Ozaki Yukihiro
Department of Chemistry, School of Science and Technology, Kwansei-Gakuin University, Sanda 669-1337, Japan.
Langmuir. 2007 Mar 27;23(7):3750-61. doi: 10.1021/la0625998. Epub 2007 Mar 3.
A process of water sorption into a biocompatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was investigated by time-resolved, in situ, attenuated total reflection infrared spectroscopy. Evidence for three different types of hydrated water in PMEA, that is, nonfreezing water, freezing bound water, and freezing water, were found. Each hydration structure was elucidated at the functional group level. Nonfreezing water, which never crystallizes, even at -100 degrees C, has a C=O...H-O type of hydrogen bonding interaction with the carbonyl group of PMEA. Freezing bound water, which crystallizes in a heating process below 0 degrees C, interacts with the methoxy moiety in the PMEA side chain terminal. Freezing water, which crystallizes approximately 0 degrees C, has bulk-water-like structure with an O-H...O-H hydrogen bonds network. It has been concluded from the present study that the methoxy moiety in the PMEA side chain terminal plays an important role for the excellent biocompatibility of PMEA.
通过时间分辨原位衰减全反射红外光谱法研究了水吸附到生物相容性聚合物聚（2-甲氧基乙基丙烯酸酯）（PMEA）中的过程。发现了PMEA中三种不同类型的水合水，即不冻水、冻结结合水和冻结水。在官能团水平上阐明了每种水合结构。即使在-100℃也不会结晶的不冻水与PMEA的羰基具有C=O...H-O型氢键相互作用。在低于0℃的加热过程中结晶的冻结结合水与PMEA侧链末端的甲氧基部分相互作用。在约0℃结晶的冻结水具有类似大量水的结构，带有O-H...O-H氢键网络。从本研究得出的结论是，PMEA侧链末端的甲氧基部分对PMEA优异的生物相容性起着重要作用。
