Attanasio Andrea F, Shalet Stephen M
Cascina del Rosone, Via Monsarinero 45, 14041 Agliano Terme, Italy.
Endocrinol Metab Clin North Am. 2007 Mar;36(1):187-201. doi: 10.1016/j.ecl.2006.11.002.
With modern growth hormone (GH) replacement algorithms, children with a diagnosis of growth hormone deficiency achieve at the end of pediatric GH treatment an adult height that is on the average in the normal range. Recent experience with GH replacement in young adults with childhood-onset growth hormone deficiency, however, has shown that these patients present with variable degrees of somatic immaturity. As childhood GH treatment is discontinued when final height is attained, attention moves to the phase of somatic development that follows the end of longitudinal growth, called ''transition'', which had been excluded previously from consideration for either pediatric or adult GH replacement. This article reviews the changes taking place during this phase of development and their relevance for the attainment of adult body maturation. The critical role of GH in this process is described.
采用现代生长激素（GH）替代方案，被诊断为生长激素缺乏的儿童在儿科GH治疗结束时达到的成人身高平均处于正常范围。然而，近期针对患有儿童期起病的生长激素缺乏的年轻成人进行GH替代治疗的经验表明，这些患者存在不同程度的躯体发育不成熟。由于达到最终身高时儿童期GH治疗即停止，关注点便转移到纵向生长结束后的躯体发育阶段，即所谓的“过渡期”，此前该阶段在儿科或成人GH替代治疗中均未被纳入考虑。本文综述了这一发育阶段所发生的变化及其与实现成人体质成熟的相关性。文中描述了GH在这一过程中的关键作用。
