Growth hormone supplementation in the elderly.

The imminent rapid increase in numbers of aging adults will significantly impact society and the health system in the coming years. The imperative is to allow older adults to maintain their independence and health for as long as possible and to prevent the ravages of chronic diseases and disabilities or the development of frailty. Significant hormonal changes are observed with aging (eg, decline in growth hormone [GH]), and strikingly similar changes in body composition are seen in GH-deficient adults and during aging. This article reviews some of the studies describing the effects of GH and GH secretagogues on body composition and functionality in the elderly. In addition, safety concerns and the need for further controlled studies of these therapies in the elderly are discussed.