自闭症个体脑电图相干性所反映的静息态皮质连通性。
Resting state cortical connectivity reflected in EEG coherence in individuals with autism.
作者信息
Murias Michael, Webb Sara J, Greenson Jessica, Dawson Geraldine
机构信息
University of Washington Autism Center, Seattle, Washington 98195, USA.
出版信息
Biol Psychiatry. 2007 Aug 1;62(3):270-3. doi: 10.1016/j.biopsych.2006.11.012. Epub 2007 Mar 6.
Abstract
BACKGROUND
Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.
METHODS
Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.
RESULTS
In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.
CONCLUSIONS
Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.
摘要
背景
自闭症谱系障碍（ASD）的理论概念以及脑血流的实验研究表明，ASD患者分布式神经系统之间的连接存在异常。
方法
对18名成年ASD患者和18名对照成年受试者在闭眼静息状态下，通过高密度电极阵列中电极对之间在窄频带内的脑电图相干性来评估功能连接性。
结果
在θ波（3 - 6赫兹）频率范围内，ASD组局部相干性明显升高，尤其是在左半球额叶和颞叶区域内。在较低的α波范围（8 - 10赫兹），ASD组在额叶区域内以及额叶与所有其他头皮区域之间的整体相干性明显降低。ASD组在3至6赫兹和13至17赫兹之间表现出显著更高的相对功率，而在9至10赫兹之间相对功率显著更低。
结论
在闭眼静息状态下，ASD受试者在不同的空间和时间尺度上存在明显的连接过度和连接不足的稳健模式。
相似文献
1
Resting state cortical connectivity reflected in EEG coherence in individuals with autism.自闭症个体脑电图相干性所反映的静息态皮质连通性。
Biol Psychiatry. 2007 Aug 1;62(3):270-3. doi: 10.1016/j.biopsych.2006.11.012. Epub 2007 Mar 6.
2
A big-world network in ASD: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections.ASD 中的大世界网络：动态连通性分析反映了长程连接的缺陷和短程连接的过剩。
Neuropsychologia. 2011 Jan;49(2):254-63. doi: 10.1016/j.neuropsychologia.2010.11.024. Epub 2010 Nov 24.
3
Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology.自闭症谱系障碍中默认模式网络的神经同步变化模式通过脑磁图（MEG）揭示：与临床症状的关系。
Autism Res. 2018 Mar;11(3):434-449. doi: 10.1002/aur.1908. Epub 2017 Dec 18.
4
Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study.自闭症患者大脑视觉皮层与其他区域之间连接增强：一项 REM 睡眠 EEG 相干性研究。
Autism Res. 2010 Oct;3(5):280-5. doi: 10.1002/aur.155.
5
Developmental changes of functional and directed resting-state connectivities associated with neuronal oscillations in EEG.发展过程中与 EEG 中神经元振荡相关的功能连接和定向静息状态连接的变化。
Neuroimage. 2013 Nov 1;81:231-242. doi: 10.1016/j.neuroimage.2013.04.030. Epub 2013 May 1.
6
Electrophysiological signatures of atypical intrinsic brain connectivity networks in autism.自闭症中非典型内在大脑连接网络的电生理特征。
J Neural Eng. 2017 Aug;14(4):046010. doi: 10.1088/1741-2552/aa6b6b.
7
EEG power and coherence in autistic spectrum disorder.自闭症谱系障碍中的脑电图功率与相干性
Clin Neurophysiol. 2008 May;119(5):1002-9. doi: 10.1016/j.clinph.2008.01.013. Epub 2008 Mar 10.
8
Joint analysis of band-specific functional connectivity and signal complexity in autism.自闭症中频段特异性功能连接性与信号复杂性的联合分析
J Autism Dev Disord. 2015 Feb;45(2):444-60. doi: 10.1007/s10803-013-1915-7.
9
EEG resting-state functional connectivity: evidence for an imbalance of external/internal information integration in autism.静息态脑电图功能连接：孤独症中外在/内在信息整合失衡的证据。
J Neurodev Disord. 2022 Aug 27;14(1):47. doi: 10.1186/s11689-022-09456-8.
10
Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder.简短报告：自闭症谱系障碍青少年在联合注意感知过程中颞中央脑电图α波连贯性降低。
J Autism Dev Disord. 2016 Apr;46(4):1477-89. doi: 10.1007/s10803-015-2667-3.
引用本文的文献
1
Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.利用人工智能驱动的神经影像生物标志物进行自闭症谱系障碍的早期检测和社会功能预测：一项系统综述。
Healthcare (Basel). 2025 Jul 22;13(15):1776. doi: 10.3390/healthcare13151776.
2
Attentional and electrophysiological associations with executive function ability in young autistic children.年幼儿童自闭症患者的注意力、电生理与执行功能能力的关联
Sci Rep. 2025 Jul 10;15(1):24883. doi: 10.1038/s41598-025-06006-9.
3
Multi-level treatment outcome evaluation in adolescents with autism spectrum disorder.自闭症谱系障碍青少年的多层次治疗效果评估。
Child Adolesc Psychiatry Ment Health. 2025 May 19;19(1):58. doi: 10.1186/s13034-025-00909-1.
4
ADHD detection from EEG signals using GCN based on multi-domain features.基于多域特征的图卷积网络从脑电图信号中检测注意力缺陷多动障碍
Front Neurosci. 2025 Apr 4;19:1561994. doi: 10.3389/fnins.2025.1561994. eCollection 2025.
5
EEG during dynamic facial emotion processing reveals neural activity patterns associated with autistic traits in children.动态面部表情情绪处理过程中的脑电图揭示了与儿童自闭症特征相关的神经活动模式。
Cereb Cortex. 2025 Feb 5;35(2). doi: 10.1093/cercor/bhaf020.
6
Individuals with high autistic traits exhibit altered interhemispheric brain functional connectivity patterns.具有高自闭症特质的个体表现出半球间大脑功能连接模式的改变。
Cogn Neurodyn. 2025 Dec;19(1):9. doi: 10.1007/s11571-024-10213-x. Epub 2025 Jan 9.
7
Shared oscillatory mechanisms of alpha-band activity in prefrontal regions in eyes open and closed state using a portable EEG acquisition device.使用便携式 EEG 采集设备，在睁眼和闭眼状态下，前额叶区域α 波段活动的共享振荡机制。
Sci Rep. 2024 Nov 4;14(1):26719. doi: 10.1038/s41598-024-78173-0.
8
Model selection to achieve reproducible associations between resting state EEG features and autism.基于模型选择实现静息态 EEG 特征与自闭症之间可重现的关联。
Sci Rep. 2024 Oct 25;14(1):25301. doi: 10.1038/s41598-024-76659-5.
9
EEG During Dynamic Facial Emotion Processing Reveals Neural Activity Patterns Associated with Autistic Traits in Children.动态面部表情处理过程中的脑电图揭示了与儿童自闭症特征相关的神经活动模式。
bioRxiv. 2024 Aug 28:2024.08.27.609816. doi: 10.1101/2024.08.27.609816.
10
Assessing the impact of repetitive transcranial magnetic stimulation on effective connectivity in autism spectrum disorder: An initial exploration using TMS-EEG analysis.评估重复经颅磁刺激对自闭症谱系障碍有效连接性的影响：使用TMS-EEG分析的初步探索。
Heliyon. 2024 May 22;10(11):e31746. doi: 10.1016/j.heliyon.2024.e31746. eCollection 2024 Jun 15.
本文引用的文献
1
Functional connectivity in a baseline resting-state network in autism.自闭症患者基线静息态网络中的功能连接性。
Neuroreport. 2006 Nov 6;17(16):1687-90. doi: 10.1097/01.wnr.0000239956.45448.4c.
2
Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence.脑电图相干性反映健康儿童和多动症儿童额叶皮质的功能连接性。
Cereb Cortex. 2007 Aug;17(8):1788-99. doi: 10.1093/cercor/bhl089. Epub 2006 Oct 5.
3
Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy.自闭症的神经病理学和遗传学发现：一种假定的小柱病变的意义。
Neuroscientist. 2006 Oct;12(5):435-41. doi: 10.1177/1073858406290375.
4
Minicolumnar abnormalities in autism.自闭症中的微小柱状结构异常。
Acta Neuropathol. 2006 Sep;112(3):287-303. doi: 10.1007/s00401-006-0085-5. Epub 2006 Jul 4.
5
Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry.自闭症中功能性和解剖学上的皮质连接不足：来自一项关于执行功能任务的功能磁共振成像研究和胼胝体形态测量的证据。
Cereb Cortex. 2007 Apr;17(4):951-61. doi: 10.1093/cercor/bhl006. Epub 2006 Jun 13.
6
Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection.自闭症患者的额叶皮质为何可能只与自身进行交流：局部过度连接但远距离断开连接。
Curr Opin Neurobiol. 2005 Apr;15(2):225-30. doi: 10.1016/j.conb.2005.03.001.
7
Functional connectivity in an fMRI working memory task in high-functioning autism.高功能自闭症患者在功能磁共振成像工作记忆任务中的功能连接性
Neuroimage. 2005 Feb 1;24(3):810-21. doi: 10.1016/j.neuroimage.2004.09.028. Epub 2004 Nov 24.
8
Autism and abnormal development of brain connectivity.自闭症与大脑连接的异常发育。
J Neurosci. 2004 Oct 20;24(42):9228-31. doi: 10.1523/JNEUROSCI.3340-04.2004.
9
Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity.高功能自闭症患者句子理解过程中的皮质激活与同步：连接不足的证据。
Brain. 2004 Aug;127(Pt 8):1811-21. doi: 10.1093/brain/awh199. Epub 2004 Jun 23.
10
Localization of white matter volume increase in autism and developmental language disorder.自闭症和发育性语言障碍中白质体积增加的定位
Ann Neurol. 2004 Apr;55(4):530-40. doi: 10.1002/ana.20032.
Zotero 插件