Murias Michael, Webb Sara J, Greenson Jessica, Dawson Geraldine
University of Washington Autism Center, Seattle, Washington 98195, USA.
Biol Psychiatry. 2007 Aug 1;62(3):270-3. doi: 10.1016/j.biopsych.2006.11.012. Epub 2007 Mar 6.
Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.
Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.
In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.
Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.
自闭症谱系障碍（ASD）的理论概念以及脑血流的实验研究表明，ASD患者分布式神经系统之间的连接存在异常。
对18名成年ASD患者和18名对照成年受试者在闭眼静息状态下，通过高密度电极阵列中电极对之间在窄频带内的脑电图相干性来评估功能连接性。
在θ波（3 - 6赫兹）频率范围内，ASD组局部相干性明显升高，尤其是在左半球额叶和颞叶区域内。在较低的α波范围（8 - 10赫兹），ASD组在额叶区域内以及额叶与所有其他头皮区域之间的整体相干性明显降低。ASD组在3至6赫兹和13至17赫兹之间表现出显著更高的相对功率，而在9至10赫兹之间相对功率显著更低。
在闭眼静息状态下，ASD受试者在不同的空间和时间尺度上存在明显的连接过度和连接不足的稳健模式。
