来自 Guyon 大戟的二萜类化合物和三萜类化合物。

Diterpenoids and triterpenoids from Euphorbia guyoniana.

作者信息

Haba Hamada, Lavaud Catherine, Harkat Hassina, Alabdul Magid Abdulmagid, Marcourt Laurence, Benkhaled Mohammed

机构信息

Laboratoire de Chimie et Chimie de l'Environnement (L.C.C.E), Département de Chimie, Faculté des Sciences, Université de Batna, Batna 05000, Algeria.

出版信息

Phytochemistry. 2007 May;68(9):1255-60. doi: 10.1016/j.phytochem.2007.01.017. Epub 2007 Mar 6.

DOI:10.1016/j.phytochem.2007.01.017

PMID:17337022

Abstract

Two new compounds with tigliane and cycloartane skeletons: 4,12-dideoxy(4alpha)phorbol-13-hexadecanoate (1) and 24-methylenecycloartane-3,28-diol (2), respectively, in addition of four known diterpenoids and 13 triterpenoids: 3-benzoyloxy-5,15-diacetoxy-9,14-dioxojatropha-6(17),11-diene (4), ent-abieta-8(14),13(15)-dien-16,12-olide (5), ent-8alpha,14alpha-epoxyabieta-11,13(15)-dien-16,12-olide (6), ent-3-hydroxyatis-16(17)-ene-2,14-dione (7), 3beta-hydroxytaraxer-14-en-28-oic acid (8), beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (9), multiflorenyl acetate (10), multiflorenyl palmitate (11), peplusol (12), 24-methylenecycloartanol (3), lanosterol (13), euferol (14), butyrospermol (15), cycloartenol (16), obtusifoliol (17), cycloeucalenol (18) and beta-sitosterol (19), were isolated from the roots of Euphorbia guyoniana. Their structures were established on the basis of physical and spectroscopic analysis, including 1D and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY) and by comparison with the literature data.

摘要

从大戟属植物圭亚那大戟的根部分离出两种具有大戟烷和环阿尔廷烷骨架的新化合物

分别为4,12-二脱氧(4α)-佛波醇-13-十六烷酸酯(1)和24-亚甲基环阿尔廷烷-3,28-二醇(2)，此外还有四种已知的二萜类化合物和13种三萜类化合物：3-苯甲酰氧基-5,15-二乙酰氧基-9,14-二氧代麻风树-6(17),11-二烯(4)、对映-枞酸-8(14),13(15)-二烯-16,12-内酯(5)、对映-8α,14α-环氧枞酸-11,13(15)-二烯-16,12-内酯(6)、对映-3-羟基阿替-16(17)-烯-2,14-二酮(7)、3β-羟基蒲公英赛-14-烯-28-酸(8)、β-谷甾醇-3β-吡喃葡萄糖苷-6'-O-棕榈酸酯(9)、多花甾醇乙酸酯(10)、多花甾醇棕榈酸酯(11)、佩普索醇(12)、24-亚甲基环阿尔廷醇(3)、羊毛甾醇(13)、优蕨醇(14)、牛油树醇(15)、环阿屯醇(16)、钝叶醇(17)、环桉叶醇(18)和β-谷甾醇(19)。它们的结构是基于物理和光谱分析确定的，包括一维和二维同核和异核核磁共振实验(COSY、HSQC、HMBC和NOESY)，并与文献数据进行比较。