Randleman J Bradley, Loft Evan S, Banning Christopher S, Lynn Michael J, Stulting R Doyle
Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.
Ophthalmology. 2007 May;114(5):983-8. doi: 10.1016/j.ophtha.2006.10.048. Epub 2007 Mar 6.
To compare early visual outcomes after wavefront-optimized advanced surface ablation (ASA) with those after wavefront-optimized LASIK.
Retrospective comparative series.
One hundred thirty-six eyes undergoing ASA and 136 preoperative refraction-matched eyes undergoing LASIK from June 2004 through October 2005.
Database review of preoperative characteristics, including patient age, gender, refraction, and central corneal pachymetry; perioperative information, including type of surgery, flap thickness (for LASIK cases), ablation depth, and residual stromal bed thickness; and postoperative information, including uncorrected visual acuity (UCVA) at 1 day, 1 week, 2 weeks, and 3 months, refraction at 3 months, and complications. All ASA patients had topical mitomycin C applied intraoperatively.
Postoperative UCVA, best spectacle-corrected visual acuity (BSCVA), spherical equivalent (SE) refraction, speed of visual recovery, and postoperative complications.
Surface ablation patients were younger (35.4 years vs. 39.8 years, P = 0.0002) and had thinner corneas (514 microm vs. 549 microm, P<0.0001) preoperatively. Average UCVA was significantly better after LASIK at 1 day (20/26.8 vs. 20/50.4, P<0.0001) and 2 weeks (20/24.4 vs. 20/33.3, P = 0.0002) postoperatively. However, by 3 months postoperatively, UCVA was better after ASA (20/20.8 vs. 20/22.7, P = 0.05), and 81.5% of patients achieved 20/20 or better UCVA after ASA, compared with 70.5% after LASIK (P = 0.05). More ASA eyes had postoperative UCVA that achieved or surpassed preoperative BSCVA than LASIK eyes (66% vs. 41.6%, P<0.0001). There were 53 patients who underwent bilateral simultaneous ASA. By 1 week, 87.5% had 20/40 or better UCVA in at least one eye and 62.5% had 20/40 or better UCVA in both eyes. By 2 weeks, 86.8% had 20/40 or better UCVA in one eye and 82.6% had 20/40 or better UCVA in both eyes.
Initial visual recovery is more rapid after LASIK; however, by 3 months postoperatively UCVA and SE refractions were better after ASA. Advanced surface ablation is an effective alternative to LASIK, and based on early visual recovery, bilateral simultaneous surface ablation is a reasonable alternative to sequential surgery for the majority of patients.
比较波前优化的准分子激光上皮瓣下角膜磨镶术(ASA)与波前优化的准分子原位角膜磨镶术(LASIK)后的早期视觉效果。
回顾性比较系列研究。
2004年6月至2005年10月期间接受ASA手术的136只眼以及136只术前屈光匹配并接受LASIK手术的对照眼。
回顾性分析术前特征数据库,包括患者年龄、性别、屈光状态及中央角膜厚度;围手术期信息,包括手术类型、瓣厚度(LASIK病例)、切削深度及剩余基质床厚度;术后信息,包括术后1天、1周、2周及3个月时的裸眼视力(UCVA)、3个月时的屈光状态及并发症。所有ASA患者术中均使用了局部丝裂霉素C。
术后UCVA、最佳矫正视力(BSCVA)、等效球镜(SE)屈光、视力恢复速度及术后并发症。
表面切削组患者术前年龄较轻(35.4岁对39.8岁,P = 0.0002),角膜较薄(514微米对549微米,P<0.0001)。术后1天(20/26.8对20/50.4,P<0.0001)及2周时(20/24.4对20/33.3,P = 0.0002),LASIK组的平均UCVA显著优于ASA组。然而,术后3个月时,ASA组的UCVA更佳(20/20.8对20/22.7,P = 0.05),ASA组81.5%的患者UCVA达到或超过20/20,而LASIK组为70.5%(P = 0.05)。ASA组术后UCVA达到或超过术前BSCVA的眼数多于LASIK组(66%对41.6%,P<0.0001)。53例患者接受了双眼同时ASA手术。至术后1周时,87.5%的患者至少一只眼UCVA达到20/40或更好,62.5%的患者双眼UCVA达到20/40或更好。至术后2周时,86.8%的患者一只眼UCVA达到20/40或更好,82.6%的患者双眼UCVA达到20/40或更好。
LASIK术后早期视力恢复更快;然而,术后3个月时ASA组的UCVA及SE屈光状态更佳。准分子激光上皮瓣下角膜磨镶术是LASIK的一种有效替代方法,基于早期视力恢复情况,对于大多数患者而言,双眼同时表面切削术是分期手术的合理替代方案。