TIM基因家族的免疫调节
Immune regulation by the TIM gene family.
作者信息
de Souza Anjali J, Kane Lawrence P
机构信息
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
出版信息
Immunol Res. 2006;36(1-3):147-55. doi: 10.1385/IR:36:1:147.
PMID:17337775
Abstract
Recent studies have demonstrated that proteins of the T cell immunoglobulin and mucin domain (TIM) family are important regulators of immune function. Here we discuss the functional effects of TIM proteins on immune responses, how the effects of TIM proteins may be modulated by interactions with ligands and the limited information available on intracellular signals downstream of TIM proteins.
摘要
近期研究表明，T细胞免疫球蛋白和粘蛋白结构域（TIM）家族的蛋白质是免疫功能的重要调节因子。在此，我们讨论TIM蛋白对免疫反应的功能影响、TIM蛋白的效应如何通过与配体的相互作用进行调节，以及关于TIM蛋白下游细胞内信号的有限信息。
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