Department of Pathology and Diagnostics, Section of General Pathology, University of Verona, Strada le Grazie 8, 37134 Verona, Italy.
Department of Pathology and Diagnostics, Section of General Pathology, University of Verona, Strada le Grazie 8, 37134 Verona, Italy.
Trends Mol Med. 2014 Dec;20(12):675-84. doi: 10.1016/j.molmed.2014.10.003. Epub 2014 Oct 31.
Leukocyte trafficking is generally considered the initial stage of any immune response, and it involves a multistep intravascular process including capture, rolling, activation, arrest, crawling, and transmigration. Both capture and rolling are predominantly mediated by selectins, which allow circulating leukocytes to sense activating signals on the endothelium and adhere to vessel walls. In this review, we discuss recent data showing that the T cell immunoglobulin and mucin domain 1 (TIM-1) protein is a major ligand for endothelial P-selectin, mediating T helper (Th) cell Th1 and Th17 trafficking in inflamed tissues. We highlight structural and functional features showing that TIM-1 can be included in the restricted group of major adhesion receptors involved in leukocyte trafficking with a pathophysiological role in inflammation and autoimmunity.
白细胞迁移通常被认为是任何免疫反应的初始阶段，它涉及一个多步骤的血管内过程，包括捕获、滚动、激活、停滞、爬行和迁移。捕获和滚动主要由选择素介导，使循环白细胞能够感知内皮细胞上的激活信号，并黏附在血管壁上。在这篇综述中，我们讨论了最近的数据，表明 T 细胞免疫球蛋白和粘蛋白结构域 1（TIM-1）蛋白是内皮 P 选择素的主要配体，介导辅助性 T 细胞（Th）在炎症组织中的 Th1 和 Th17 迁移。我们强调了结构和功能特征，表明 TIM-1 可以被包括在涉及白细胞迁移的少数主要黏附受体中，在炎症和自身免疫中具有病理生理学作用。
