Su Ee Wern, Lin Jean Y, Kane Lawrence P
Department of Immunology, University of Pittsburgh, 200 Lothrop street, BST E-1056, Pittsburgh, PA 15261, USA.
Cytokine. 2008 Oct;44(1):9-13. doi: 10.1016/j.cyto.2008.06.013. Epub 2008 Aug 15.
Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss in this review. We therefore propose that the definition of TIM be adjusted to "transmembrane immunoglobulin and mucin".
在过去几年中，人们对TIM（T细胞免疫球蛋白和粘蛋白结构域）家族蛋白在调节免疫反应中的作用越来越感兴趣。尽管这个名字暗示了其作用对象，但正如我们将在本综述中讨论的那样，该家族蛋白的功能远比仅作用于T细胞更为广泛。因此，我们建议将TIM的定义调整为“跨膜免疫球蛋白和粘蛋白”。
