Brotman Melissa A, Rich Brendan A, Schmajuk Mariana, Reising Michelle, Monk Christopher S, Dickstein Daniel P, Mogg Karin, Bradley Brendan P, Pine Daniel S, Leibenluft Ellen
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Biol Psychiatry. 2007 Mar 15;61(6):819-21. doi: 10.1016/j.biopsych.2006.08.021.
Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness.
Pediatric BD with lifetime anxiety (BD+ANX, n = 20), BD without lifetime anxiety (BD-ANX, n = 11), and controls (n = 14) were administered the visual-probe paradigm, which assesses attention bias to threat faces.
Bipolar disorder +ANX demonstrated a stronger bias toward threat relative to BD-ANX and controls; the latter two did not differ from each other.
Bipolar disorder +ANX showed a bias toward threat while, in two previous studies, anxious children showed a bias away from threat faces. Future studies should compare the pathophysiology of BD with and without a comorbid anxiety disorder and anxiety disorders presenting alone.
尽管共病焦虑症在双相情感障碍（BD）儿童中很常见，但尚不清楚这种共病如何影响该疾病的病理生理学。
对有终生焦虑症的儿童双相情感障碍患者（BD+ANX，n = 20）、无终生焦虑症的双相情感障碍患者（BD-ANX，n = 11）和对照组（n = 14）进行视觉探测范式测试，该测试评估对威胁面孔的注意偏向。
双相情感障碍+焦虑症组相对于双相情感障碍-焦虑症组和对照组表现出更强的对威胁的偏向；后两组之间没有差异。
双相情感障碍+焦虑症组表现出对威胁的偏向，而在前两项研究中，焦虑儿童表现出对威胁面孔的回避偏向。未来的研究应比较有或无共病焦虑症的双相情感障碍以及单独出现的焦虑症的病理生理学。
