着丝粒染色质被加载。
Centromeric chromatin gets loaded.
作者信息
Carroll Christopher W, Straight Aaron F
机构信息
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
出版信息
J Cell Biol. 2007 Mar 12;176(6):735-6. doi: 10.1083/jcb.200702020. Epub 2007 Mar 5.
Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein required for CENP-A deposition. Together, these studies advance our understanding of centromeric chromatin assembly and provide a framework for investigating the molecular mechanisms that underlie the centromere-specific loading of CENP-A.
着丝粒核小体包含一种名为着丝粒蛋白A（CENP - A）的组蛋白H3变体，它是动粒组装和染色体分离所必需的。两项新的研究，詹森等人（见本期第795页）和马多克斯等人（见本期第757页），探讨了CENP - A在细胞分裂周期中何时沉积在着丝粒上，并鉴定出一种CENP - A沉积所需的进化保守蛋白。这些研究共同推进了我们对着丝粒染色质组装的理解，并为研究CENP - A着丝粒特异性加载背后的分子机制提供了一个框架。
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