Giacomini K M, Brett C M, Altman R B, Benowitz N L, Dolan M E, Flockhart D A, Johnson J A, Hayes D F, Klein T, Krauss R M, Kroetz D L, McLeod H L, Nguyen A T, Ratain M J, Relling M V, Reus V, Roden D M, Schaefer C A, Shuldiner A R, Skaar T, Tantisira K, Tyndale R F, Wang L, Weinshilboum R M, Weiss S T, Zineh I
Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, USA.
Clin Pharmacol Ther. 2007 Mar;81(3):328-45. doi: 10.1038/sj.clpt.6100087.
The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators with a wide range of research interests, but all attempting to correlate drug response with genetic variation. Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). The diverse scientific information is stored and annotated in a publicly accessible knowledge base, the Pharmacogenetics and Pharmacogenomics Knowledge base (PharmGKB). This report highlights selected achievements and scientific approaches as well as hypotheses about future directions of each of the groups within the PGRN. Seven major topics are included: informatics (PharmGKB), cardiovascular, pulmonary, addiction, cancer, transport, and metabolism.
美国国立卫生研究院药物基因组学研究网络（PGRN）是一个由研究兴趣广泛的研究人员组成的合作团队，他们都致力于将药物反应与基因变异联系起来。几个研究小组专注于用于治疗特定医学疾病（哮喘、抑郁症、心血管疾病、尼古丁成瘾和癌症）的药物，而其他小组则专注于与药物相互作用的特定蛋白质组（膜转运蛋白和II期药物代谢酶）。这些多样的科学信息被存储并注释在一个可公开访问的知识库——药物基因组学和药物基因组学知识库（PharmGKB）中。本报告重点介绍了PGRN内各小组的选定成就、科学方法以及关于未来方向的假设。报告涵盖七个主要主题：信息学（PharmGKB）、心血管、肺部、成瘾、癌症、转运和代谢。
