黄药子细胞培养物中的抗炎化合物 1.

Antiinflammatory Compounds from Plagiorhegma dubium Cell Culture1.

机构信息

A. Nattermann & Cie. GmbH, P.O. Box 350120, D-5000 Cologne 30.

出版信息

Planta Med. 1985 Feb;51(1):52-6. doi: 10.1055/s-2007-969392.

DOI:10.1055/s-2007-969392

Abstract

Successive fractionation of a crude methanolic extract of cultured PLAGIORHEGMA DUBIUM cells, followed by assay of the biological activity using cobra venom factor induced paw oedema, led to the detection and isolation of three compounds with antiinflammatory activity. The substances were identified as the protoberberine alkaloid jatrorrhizine and the lignaneglucosides dehydrodiconiferyl-alcohol-4-beta- D-glucoside and its isomer dehydrodiconiferyl-alcohol-gamma-beta- D-glucoside, the latter a compound not previously described in the literature.

摘要

从培养的 PLAGIORHEGMA DUBIUM 细胞的粗甲醇提取物中进行连续分级分离，然后使用眼镜蛇毒液因子诱导的爪肿胀测定生物活性，检测到并分离出三种具有抗炎活性的化合物。这些物质被鉴定为原小檗碱生物碱黄连碱和木脂素葡萄糖苷去氢二松柏醇-4-β-D-葡萄糖苷及其异构体去氢二松柏醇-γ-β-D-葡萄糖苷，后者是文献中以前未描述的化合物。