Huang Tsai-Wang, Wang Chih-Hsin, Hsieh Chung-Bao
Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Onkologie. 2007 Mar;30(3):129-31. doi: 10.1159/000098853. Epub 2007 Feb 13.
Cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium. The disease is notoriously difficult to diagnose and is usually fatal because of its late clinical presentation and the lack of effective nonsurgical therapeutic modalities. The overall survival rate, including in patients who underwent tumor resections, is poor, with less than 5% surviving more than 5 years. Over the past 5 years, several important studies have yielded new insight into the molecular mechanisms involved in the development and growth of these tumors. The tumor cells of the cholangiocarcinoma express an epidermal growth factor receptor which plays an important role in the pathogenesis of these tumors.
A 49-year-old woman with cholangiocarcinoma of the liver developed spinal metastases. The antiepidermal growth factor receptor (anti-EGFR) antibody was used successfully in combination with radiotherapy. The response to treatment was assessed by magnetic resonance imaging and positron-emission tomography.
The patient with cholangiocarcinoma had a response to cetuximab-based therapies. This may lead to another option for the treatment of hepatic cholangiocarcinoma.
胆管癌是一种起源于胆管上皮的恶性肿瘤。该疾病 notoriously难以诊断，并且由于其临床症状出现较晚以及缺乏有效的非手术治疗方式，通常是致命的。总体生存率较差，包括接受肿瘤切除的患者在内，存活超过5年的不到5%。在过去5年中，几项重要研究对这些肿瘤发生和生长所涉及的分子机制有了新的认识。胆管癌的肿瘤细胞表达一种表皮生长因子受体，其在这些肿瘤的发病机制中起重要作用。
一名49岁的肝胆管癌女性发生了脊柱转移。抗表皮生长因子受体（anti-EGFR）抗体与放疗联合使用取得了成功。通过磁共振成像和正电子发射断层扫描评估治疗反应。
胆管癌患者对基于西妥昔单抗的治疗有反应。这可能为肝胆管癌的治疗带来另一种选择。
