Medvetz Doug A, Stakleff Kimberly D, Schreiber Tara, Custer Paul D, Hindi Khadijah, Panzner Matthew J, Blanco Denise D, Taschner Michael J, Tessier Claire A, Youngs Wiley J
The University of Akron, 190 East Buchtel Commons, Akron, Ohio 44325, USA.
J Med Chem. 2007 Apr 5;50(7):1703-6. doi: 10.1021/jm060857s. Epub 2007 Mar 8.
A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.
一种硫醚金属配合物1-氮杂-4,7-二硫杂环壬烷-RhCl3（2）以及环胺金属配合物三环己基胺-CuBr2（3）和三甲基三环己基胺-RuCl3（4），已针对卵巢癌细胞系NuTu-19的抗癌活性以及对非癌性卵巢组织细胞系OVepi的细胞毒性进行了评估。具体而言，使用MTT和细胞侵袭试验，在微摩尔浓度下，金属配合物2与顺铂相比具有活性。所报道的体外结果值得在活体系统中对金属配合物2进行进一步评估。
