Papakonstantinou Vasiliki D, Lagopati Nefeli, Tsilibary Effie C, Demopoulos Constantinos A, Philippopoulos Athanassios I
Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Institute of Biosciences & Applications, NCSR Demokritos, 15310 Agia Paraskevi, Greece.
Bioinorg Chem Appl. 2017;2017:6947034. doi: 10.1155/2017/6947034. Epub 2017 Mar 28.
In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary relationships for the different classes of metal-based inhibitors.
在本综述中，我们提及了血小板活化因子（PAF）抑制剂的最新研究成果。首先，报道了作为PAF抑制剂的有机化合物（天然和合成的、特异性和非特异性的）的研究结果。重点介绍了一类新型所谓的基于金属的PAF抑制剂的最新研究成果。由此构建了一个包含30种金属配合物的小型文库；由于它们对洗涤过的兔血小板（WRP）中PAF的抑制作用，其抗炎活性得到了进一步评估。此外，还重点探讨了不同类型基于金属的抑制剂之间初步关系的确定。
