来自水蓑衣的三萜皂苷及其在两种小鼠模型中的抗抑郁作用。

Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models.

作者信息

Zhou Yun, Shen Yun-Heng, Zhang Chuan, Su Juan, Liu Run-Hui, Zhang Wei-Dong

机构信息

Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.

出版信息

J Nat Prod. 2007 Apr;70(4):652-5. doi: 10.1021/np060470s. Epub 2007 Mar 8.

DOI:10.1021/np060470s

PMID:17343408

Abstract

Three new triterpene glycosides, bacopasides VI-VIII (1-3), together with three known analogues, bacopaside I (4), bacopaside II (5), and bacopasaponsin C (6), were isolated from the whole plant of Bacopa monnieri. Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively.

摘要

从假马齿苋的全株中分离出三种新的三萜糖苷，即假马齿苋皂苷VI - VIII（1 - 3），以及三种已知类似物，假马齿苋皂苷I（4）、假马齿苋皂苷II（5）和假马齿苋皂苷C（6）。化合物4、5和6分别在小鼠的强迫游泳和悬尾实验中表现出抗抑郁活性。