假马齿苋全草中各成分的化学结构。
Chemical structures of constituents from the whole plant of Bacopa monniera.
作者信息
Ohta Tomoe, Nakamura Seikou, Nakashima Souichi, Oda Yoshimi, Matsumoto Takahiro, Fukaya Masashi, Yano Mamiko, Yoshikawa Masayuki, Matsuda Hisashi
机构信息
Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
N.T.H Co., Ltd., 4F Sky-ebisu Bldg., 1-8-11 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan.
出版信息
J Nat Med. 2016 Jul;70(3):404-11. doi: 10.1007/s11418-016-0986-0. Epub 2016 Mar 24.
Two new dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B1, and B2, were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera. This is the first report of acylated dammarane-type triterpene oligoglycosides isolated from B. monniera. In addition, dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.
从假马齿苋的全株中分离出两种新的达玛烷型三萜寡糖苷，即假马齿苋皂苷A和B，以及三种新的苯乙醇苷，即假马齿苋苷A、B1和B2。根据化学和物理化学证据对新成分的化学结构进行了表征。在本研究中，从假马齿苋全株中获得了带有酰基的假马齿苋皂苷A和B。这是首次从假马齿苋中分离出酰化达玛烷型三萜寡糖苷的报道。此外，达玛烷型三萜皂苷显著抑制了42聚体淀粉样β蛋白的聚集。
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