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[垂体-肾上腺轴对大鼠和金黄仓鼠棕色脂肪组织的影响]

[Influence of the pituitary-adrenal axis on the brown fat tissue of the rat and golden hamster].

作者信息

Pellet H, Guerrier D, Thonnerieux M, Vigier M

出版信息

Bull Assoc Anat (Nancy). 1975 Jun;59(165):479-88.

PMID:173443
Abstract

The suppression or reduction of the adrenal secretion in the Rat and in the golden Hamster results in a reduction of the weight of brown adipose tissue and of the volume of intra cytoplasmic vacuoles. When corticotropin is given to normal and hypophysectomized animals, the intra cytoplasmic vacuolar system and the corticosterone concentration of brown fat increase. After sham hypophysectomy and short ether intake, a considerable lipidic depletion and a high level of corticosterone are observed. The authors speculate that the by adrenaline. The morphologic responses are much more intense and rapid lipid content of brown adipose tissue is increased by corticotropin and reduced by adrenaline. The morphologic responses are much more intense and rapid in brown adipose tissue than in white adipose tissue.

摘要

对大鼠和金黄仓鼠肾上腺分泌的抑制或减少会导致棕色脂肪组织重量减轻以及细胞质内液泡体积减小。当向正常动物和垂体切除动物注射促肾上腺皮质激素时,棕色脂肪的细胞质内液泡系统和皮质酮浓度会增加。在假垂体切除和短期吸入乙醚后,会观察到大量脂质消耗和高水平的皮质酮。作者推测棕色脂肪组织的脂质含量会因促肾上腺皮质激素而增加,因肾上腺素而减少。棕色脂肪组织中的形态学反应比白色脂肪组织中的更强烈、更迅速。

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