Dillon Robert H, Fauci Lisa J, Omoto Charlotte, Yang Xingzhou
Department of Mathematics, Washington State University, Pullman, Washington 99164, USA.
Ann N Y Acad Sci. 2007 Apr;1101:494-505. doi: 10.1196/annals.1389.016. Epub 2007 Mar 7.
We have developed a fluid-mechanical model of a eucaryotic axoneme that couples the internal force generation of dynein molecular motors, the passive elastic mechanics of microtubules, and forces due to nexin links with a surrounding incompressible fluid. This model has been used to examine both ciliary beating and flagellar motility. In this article, we show preliminary simulation results for sperm motility in both viscous and viscoelastic fluids, as well as multiciliary interaction with a mucus layer.
我们构建了一个真核生物轴丝的流体力学模型,该模型将动力蛋白分子马达产生的内力、微管的被动弹性力学以及由于连接蛋白连接产生的力与周围不可压缩流体耦合在一起。这个模型已被用于研究纤毛摆动和鞭毛运动。在本文中,我们展示了在粘性和粘弹性流体中精子运动的初步模拟结果,以及多纤毛与粘液层相互作用的结果。