Il'ina A V, Varlamov V P
Prikl Biokhim Mikrobiol. 2007 Jan-Feb;43(1):82-7.
Chitosan, a binary heteropolysaccharide consisting of 2-acetamide-2-deoxy-beta-D-glucopyranose and 2-amino-2-deoxy-beta-D-glucopyranose residues linked in different proportions via beta-glycosidic bonds. The presence of a primary amino group in the chitosan structure allows for the synthesis of various derivatives. The procedure of obtaining activated N-hydroxysuccinimide esters with the use of lactobionic acid was applied to obtain galactosylated derivatives of low-molecular-weight chitosan with a substitution degree varying from 8 to 23%. The properties of these derivatives (viscosity, solubility, and biodegradability) were studied. These derivatives are well soluble at pH values greater than the acidity constant of amino groups of chitosan (6.5). Broadening the pH range towards increase and the presence of galactose residues allows these derivatives to be used in working with biological objects.
壳聚糖是一种二元杂多糖，由2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖和2-氨基-2-脱氧-β-D-吡喃葡萄糖残基通过β-糖苷键以不同比例连接而成。壳聚糖结构中伯氨基的存在使得可以合成各种衍生物。采用利用乳糖酸获得活化的N-羟基琥珀酰亚胺酯的方法，得到了取代度为8%至23%的低分子量壳聚糖的半乳糖基化衍生物。研究了这些衍生物的性质（粘度、溶解性和生物降解性）。这些衍生物在pH值大于壳聚糖氨基酸度常数（6.5）时可良好溶解。向更高pH范围扩展以及半乳糖残基的存在使得这些衍生物可用于与生物对象相关的工作。
