Department of Life Sciences, University of Trieste, Via Licio Giorgieri 5, I-34127 Trieste, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazza dell'Ospitale 1, I-34129 Trieste, Italy.
Molecules. 2020 Mar 27;25(7):1534. doi: 10.3390/molecules25071534.
Chitosan derivatives, and more specifically, glycosylated derivatives, are nowadays attracting much attention within the scientific community due to the fact that this set of engineered polysaccharides finds application in different sectors, spanning from food to the biomedical field. Overcoming chitosan (physical) limitations or grafting biological relevant molecules, to mention a few, represent two cardinal strategies to modify parent biopolymer; thereby, synthetizing high added value polysaccharides. The present review is focused on the introduction of oligosaccharide side chains on the backbone of chitosan. The synthetic aspects and the effect on physical-chemical properties of such modifications are discussed. Finally, examples of potential applications in biomaterials design and drug delivery of these novel modified chitosans are disclosed.
壳聚糖衍生物，更具体地说，糖基化衍生物，由于这组工程化多糖在从食品到生物医学领域的不同领域都有应用，因此在科学界引起了广泛关注。克服壳聚糖（物理）限制或嫁接生物相关分子，仅举几例，代表了两种修饰母体生物聚合物的主要策略；从而合成高附加值多糖。本综述重点介绍了在壳聚糖主链上引入寡糖侧链。讨论了这些修饰的合成方面及其对物理化学性质的影响。最后，揭示了这些新型改性壳聚糖在生物材料设计和药物传递中的潜在应用实例。
