Spanier S S, Enneking W F, Enriquez P
Cancer. 1975 Dec;36(6):2084-98. doi: 10.1002/cncr.2820360925.
A review of over 400 primary bone tumors yielded 11 lesions with features allowing classification as malignant fibrous histiocytoma on a purely histological basis. Correlation with roentgenograms and clinical data indicated that these tumors occurred as osteolytic lesions associated with a high incidence of pathologic fractures in the metaphyses of skeletally mature long bones. Nine patients developed pulmonary metastases and 3 developed lymph node metastases within 21 months following diagnosis. The average survival was 12 months in 6 of the 9 patients who had no secondary treatment in their metastases. Treatment of 3 patients with metastatic lesions with chemotherapy or radiotherapy has been clinically encouraging. Some evidence was obtained that either or both the histiocytic and fibroblastic component may metastasize. There is a need for biopsy of metastatic lesions and autopsy followup to more accurately assess the mode of spread and histologic type of the metastases.
对400多例原发性骨肿瘤进行回顾性研究，发现有11例病变，其特征在单纯组织学基础上可归类为恶性纤维组织细胞瘤。与X线片及临床资料对比表明，这些肿瘤表现为溶骨性病变，在骨骼成熟的长骨干骺端发生病理性骨折的几率很高。9例患者在诊断后21个月内出现肺转移，3例出现淋巴结转移。9例转移后未接受二次治疗的患者中，6例的平均生存期为12个月。对3例有转移病变的患者进行化疗或放疗，临床效果令人鼓舞。有证据表明，组织细胞和成纤维细胞成分中的一种或两种都可能发生转移。需要对转移病变进行活检并进行尸检随访，以更准确地评估转移的扩散方式和组织学类型。
