Dahlin D C, Unni K K, Matsuno T
Cancer. 1977 Apr;39(4):1508-16. doi: 10.1002/1097-0142(197704)39:4<1508::aid-cncr2820390424>3.0.co;2-0.
Malignant (fibrous) histiocytoma is currently defined as a malignant primary bone tumor that contains a mixture of fibrogenic cells and cells that are histologically similar but which appear to be histiocytic. In this type of histiocytoma the nuclei are often indented; cytoplasm is usually abundant and may be slightly foamy; nucleoli are often large; and multinucleated malignant cells are usually a prominent feature. Many dedifferentiated chondrosarcomas, osteosarcomas, and fibrosarcomas of bone contain areas that resemble what we regard as malignant (fibrous) histiocytoma. When the entirety of a malignant tumor of bone fits the outlined histologic pattern, the designation of malignant (fibrous) histiocytoma seems appropriate. From 158 fibrosarcomas of bone and 962 osteosarcomas of bone in our files, 35 tumors were segregated because they appeared to be properly designated as malignant (fibrous) histiocytoma. A wide age range was represented by affected patients, and a large variety of bones harbored these tumors. Approximately one-third of patients eligible for 5-year follow-up were long-term, symptom-free survivors. Four deaths occurred from the tumor after more than 5 years, and one patient had radiographic evidence of pulmonary metastasis 7 years after amputation. Radiation therapy has been curative in at least two cases. The correct designation for these tumors in the light of current knowledge is malignant tumor, consistent with malignant (fibrous) histiocytoma.
恶性（纤维）组织细胞瘤目前被定义为一种恶性原发性骨肿瘤，它包含成纤维细胞和组织学上相似但看似组织细胞样的细胞的混合物。在这种类型的组织细胞瘤中，细胞核常呈凹陷状；细胞质通常丰富，可能略带泡沫；核仁常较大；多核恶性细胞通常是一个显著特征。许多骨的去分化软骨肉瘤、骨肉瘤和纤维肉瘤包含类似于我们所认为的恶性（纤维）组织细胞瘤的区域。当骨恶性肿瘤的整体符合所概述的组织学模式时，恶性（纤维）组织细胞瘤这一命名似乎是合适的。在我们档案中的158例骨纤维肉瘤和962例骨肉瘤中，有35例肿瘤被区分出来，因为它们似乎被恰当地认定为恶性（纤维）组织细胞瘤。受影响患者的年龄范围很广，这些肿瘤出现在各种各样的骨骼中。约三分之一有资格接受5年随访的患者是长期无症状幸存者。5年后有4例患者死于该肿瘤，1例患者在截肢7年后有肺部转移的影像学证据。放射治疗至少在两例中治愈了疾病。根据目前的认识，这些肿瘤的正确命名是恶性肿瘤，符合恶性（纤维）组织细胞瘤。
