Smith S E, Kransdorf M J
Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Semin Musculoskelet Radiol. 2000;4(1):73-88. doi: 10.1055/s-2000-6856.
Tumors of fibrous origin include fibrous dysplasia (FD), fibroxanthoma (nonossifying fibroma), cortical desmoid, desmoplastic fibroma, fibrosarcoma, and malignant fibrous histiocytosis (MFH). Benign fibrous lesions (FD, fibroxanthoma, and cortical desmoid) frequently demonstrate pathognomonic radiologic characteristics obviating the need for biopsy. Indeed, biopsy of these lesions can occasionally lead to confusion with more aggressive lesions. Desmoplastic fibroma and the malignant fibrous lesions (fibrosarcoma and MFH) often reveal nonspecific imaging features of a solitary nonmineralized lesion with aggressive characteristics. However, imaging is important as with other neoplasms in delineating the extent of involvement for staging purposes. This article reviews the spectrum of clinical characteristics, pathology, imaging appearances, treatment, and prognosis of lesions of fibrous origin in bone.
纤维源性肿瘤包括骨纤维异常增殖症（FD）、纤维黄色瘤（非骨化性纤维瘤）、皮质硬纤维瘤、促结缔组织增生性纤维瘤、纤维肉瘤和恶性纤维组织细胞瘤（MFH）。良性纤维性病变（FD、纤维黄色瘤和皮质硬纤维瘤）常表现出具有诊断意义的放射学特征，无需进行活检。实际上，对这些病变进行活检有时会导致与侵袭性更强的病变混淆。促结缔组织增生性纤维瘤和恶性纤维性病变（纤维肉瘤和MFH）通常表现为具有侵袭性特征的孤立性非矿化病变的非特异性影像学特征。然而，与其他肿瘤一样，影像学检查对于确定分期的受累范围很重要。本文综述了骨纤维源性病变的临床特征、病理、影像学表现、治疗及预后。
