Beisang A A, Ersek R A
Department of Pediatric Immunology, University of Minnesota, Minneapolis 55455.
Aesthetic Plast Surg. 1992 Winter;16(1):83-90. doi: 10.1007/BF00455154.
The development of small, textured implant particles suspended in a hydrogel has allowed for subdermal injection therapy to fill tissue defects. The microimplant particles were placed subdermally into the ears of white New Zealand rabbits in order to characterize the foreign body response and the permanence of the implant. Serial micrometer readings were performed on the implant sites to determine any change in thickness of the augmentation following baseline measurement. An initial increase in the thickness was noted approximately 20-30 days postimplantation, as expected. A stable thickness was noted for the remainder of the experiment. Serial histological sections were performed at irregular intervals from one week to one year. Histology demonstrated a mild foreign body response with collagen surrounding each individual microimplant particle. The response was stable after 30-40 days and has remained stable for over one year. It was determined that the histology demonstrated a Boros 1A type, or nonimmunogenic, low-turnover foreign body reaction.
悬浮于水凝胶中的小型带纹理植入颗粒的研发，使得皮下注射疗法能够用于填充组织缺损。将微型植入颗粒皮下植入白色新西兰兔的耳部，以表征异物反应及植入物的持久性。在植入部位进行系列微米读数，以确定基线测量后隆突厚度的任何变化。如预期的那样，植入后约20 - 30天观察到厚度初步增加。在实验的剩余时间里，厚度保持稳定。从一周到一年不定期进行系列组织学切片。组织学显示每个微型植入颗粒周围有胶原蛋白形成的轻度异物反应。30 - 40天后反应稳定，并在一年多时间里一直保持稳定。确定组织学显示为Boros 1A 型，即非免疫原性、低周转率的异物反应。
