Ersek R A, Beisang A A
Department of Plastic and Reconstructive Surgery, Southwest Texas State University, San Marcos.
Plast Reconstr Surg. 1991 Apr;87(4):693-702.
Migration, absorption, or toxicity of prosthetic materials has always plagued the plastic surgeon attempting to ameliorate soft-tissue deficiencies and other contour abnormalities. Our previous work to develop textured-surface breast prostheses has led to the development of micronized, inert, biphasic copolymer particles that neither migrate nor become absorbed by the body. These particles are textured, of critical dimension, and, when mixed with a bioexcretable gel vehicle, can be implanted using a special blunt-tipped cannula. Our experimentation in rabbit ears has shown that the bioexcretable gel component is rapidly phagocytized and is replaced by fibrin-like matrix within 3 days. The fibrin is then replaced by host collagen that gradually converts into a fibrotic encasement around each texturized particle. Clinical use of the substance in a variety of soft-tissue deficiencies has been generally effective, with only a few complications, when followed for 1 year.
假体材料的迁移、吸收或毒性一直困扰着试图改善软组织缺损和其他轮廓异常的整形外科医生。我们之前开发有纹理表面乳房假体的工作，促成了微粉化、惰性、双相共聚物颗粒的研发，这些颗粒既不会迁移也不会被身体吸收。这些颗粒有纹理、尺寸关键，并且当与可生物排泄的凝胶载体混合时，可用一种特殊的钝头套管进行植入。我们在兔耳上进行的实验表明，可生物排泄的凝胶成分会迅速被吞噬，并在3天内被纤维蛋白样基质取代。然后纤维蛋白被宿主胶原蛋白取代，宿主胶原蛋白会逐渐在每个有纹理的颗粒周围转化为纤维化包裹。该物质在各种软组织缺损中的临床应用总体上是有效的，随访1年时仅有少数并发症。
