Smahel J, Hurwitz P J, Hurwitz N
Department of Surgery, University of Zurich Medical School, Switzerland.
Plast Reconstr Surg. 1993 Sep;92(3):474-9. doi: 10.1097/00006534-199309000-00015.
In a study on rats to assess soft tissue response to textured silicone implants, ellipsoid 15 x 20 mm pieces from the bag of a Biocell breast prosthesis were implanted under the dorsal skin. Histological examinations including immunohistochemical detection of myofibroblasts were made 2 weeks and 1, 3, 6, and 8 months after implantation (12 specimens for each time interval). On the smooth side of the implant, which served as a control, the thin connective tissue capsule characteristically seen with silicone elastomer implants developed within a month. Myofibroblasts were present after the first month and appeared to reach a peak 3 months after implantation, after which they showed marked regression. On the textured side of the implant, villous processes were a characteristic feature of the capsules; originating in a common basal layer, they penetrated into the cavities of the implant. Collagen deposits and myofibroblasts only became more evident during the third month after implantation; they were limited to the common basal layer of the capsule, though foreign body reaction persisted in the villous processes until the end of the experiment. The experimental study, limited to an 8-month period after implantation, showed that texturing of the implant surface prevents compact capsule development and considerably delays or inhibits the maturation process.
在一项评估大鼠对有纹理硅胶植入物软组织反应的研究中，从一个Biocell乳房假体的袋子中取出15×20毫米的椭圆形薄片，植入大鼠背部皮肤下。在植入后2周以及1、3、6和8个月进行组织学检查，包括免疫组织化学检测肌成纤维细胞（每个时间间隔12个标本）。在作为对照的植入物光滑面，硅胶弹性体植入物典型的薄结缔组织包膜在一个月内形成。第一个月后出现肌成纤维细胞，在植入后3个月似乎达到峰值，之后显著消退。在植入物有纹理的一侧，绒毛状突起是包膜的特征性表现；它们起源于共同的基底层，穿透到植入物的腔隙中。胶原沉积和肌成纤维细胞仅在植入后第三个月变得更加明显；它们局限于包膜的共同基底层，不过直到实验结束，绒毛状突起中的异物反应仍持续存在。这项仅限于植入后8个月的实验研究表明，植入物表面的纹理化可防止致密包膜形成，并显著延迟或抑制成熟过程。
