Schattmann Linda, Sherwin Barbara B
Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1.
Horm Behav. 2007 May;51(5):579-86. doi: 10.1016/j.yhbeh.2007.02.002. Epub 2007 Feb 12.
In a previous study, we found that women with polycystic ovary syndrome (PCOS), an endocrine disorder characterized by chronic hyperandrogenism, performed more poorly than healthy, matched controls on a number of neuropsychological tests, in particular tests of verbal fluency, verbal memory, manual dexterity, and visuospatial working memory. This randomized, placebo-controlled trial was undertaken to investigate whether pharmacologic manipulation of free testosterone (free T) levels in women with PCOS might affect their performance on cognitive tests. Nineteen women with PCOS completed a battery of neuropsychological tests before and after 3 months of treatment with either an anti-androgen (cyproterone acetate) plus estrogen or with a placebo. Hormone treatment of women with PCOS caused a significant reduction in their free T levels but did not affect performance on tests visuospatial ability, verbal memory, manual dexterity, or perceptual speed. Women treated with hormone therapy did, however, demonstrate an improvement in their performance on a test of verbal fluency compared to their pre-treatment scores. These findings suggest that changes in free T levels do not have a significant impact on cognitive performance in women with PCOS, although reductions in free T may be beneficial for verbal fluency.
在之前的一项研究中，我们发现患有多囊卵巢综合征（PCOS）的女性，一种以内分泌失调和慢性雄激素过多为特征的疾病，在多项神经心理学测试中表现比健康的匹配对照组更差，尤其是在语言流畅性、言语记忆、手部灵活性和视觉空间工作记忆测试中。这项随机、安慰剂对照试验旨在研究对患有PCOS的女性进行游离睾酮（游离T）水平的药物调控是否会影响她们在认知测试中的表现。19名患有PCOS的女性在接受抗雄激素（醋酸环丙孕酮）加雌激素或安慰剂治疗3个月前后完成了一系列神经心理学测试。对患有PCOS的女性进行激素治疗导致她们的游离T水平显著降低，但并未影响视觉空间能力、言语记忆、手部灵活性或感知速度测试的表现。然而，与治疗前的分数相比，接受激素治疗的女性在语言流畅性测试中的表现确实有所改善。这些发现表明，游离T水平的变化对患有PCOS的女性的认知表现没有显著影响，尽管游离T水平的降低可能对语言流畅性有益。
