Jarrett Brittany Y, Vantman Natalie, Mergler Reid J, Brooks Eric D, Pierson Roger A, Chizen Donna R, Lujan Marla E
Division of Nutritional Sciences, Cornell University, Ithaca, New York.
Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
J Endocr Soc. 2019 Jul 30;3(10):1858-1868. doi: 10.1210/js.2019-00112. eCollection 2019 Oct 1.
Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by multiple reproductive and metabolic abnormalities. Because individual reproductive and metabolic abnormalities modulate working memory in the general population, there is growing interest in whether cognitive function is dually and negatively affected in PCOS.
To examine the association of reproductive and metabolic features with cognitive function in women with and without PCOS.
An observational, cross-sectional study was conducted at an academic clinical research center in North America between 2006 and 2009. Common tests of working memory (, manual dexterity, perceptual speed, and visuospatial ability) were performed by women with PCOS (n = 40) and control subjects (n = 40). Markers of sex steroid hormones, ovulatory function, and cardiometabolic health were also assessed.
Reduced visuospatial ability was observed in women with PCOS compared with control subjects ( < 0.01). Reduced visuospatial ability was linked to higher levels of hemoglobin A1c in the entire study cohort, independent of body mass index or PCOS status. No associations were observed between visuospatial ability and reproductive features, after controlling for confounding variables.
Our findings support a role for glycemic control, and not PCOS , in cognitive dysfunction in women of reproductive age. Additional studies are needed to understand the short- and long-term effects of dysglycemia on brain health in women with PCOS, given their increased propensity for metabolic comorbidities, compared with control subjects.
多囊卵巢综合征（PCOS）是一种复杂的内分泌疾病，其特征为多种生殖和代谢异常。由于个体的生殖和代谢异常会影响普通人群的工作记忆，因此人们越来越关注PCOS患者的认知功能是否会受到双重负面影响。
研究患有和未患有PCOS的女性的生殖和代谢特征与认知功能之间的关联。
2006年至2009年在北美的一个学术临床研究中心进行了一项观察性横断面研究。对40例PCOS女性患者和40例对照者进行了工作记忆（、手动灵活性、感知速度和视觉空间能力）的常规测试。还评估了性类固醇激素、排卵功能和心脏代谢健康的标志物。
与对照者相比，PCOS女性患者的视觉空间能力降低（<0.01）。在整个研究队列中，视觉空间能力降低与较高的糖化血红蛋白水平相关，且独立于体重指数或PCOS状态。在控制混杂变量后，未观察到视觉空间能力与生殖特征之间的关联。
我们的研究结果支持血糖控制而非PCOS在育龄女性认知功能障碍中起作用。鉴于PCOS女性患者与对照者相比代谢合并症的倾向增加，需要进一步研究以了解血糖异常对PCOS女性患者脑健康的短期和长期影响。
