Barnard L, Balen A H, Ferriday D, Tiplady B, Dye L
Clinical Psychology Training Programme, University of Leeds, 15 Hyde Terrace, Leeds LS2 9LT, UK.
Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):906-14. doi: 10.1016/j.psyneuen.2007.06.010. Epub 2007 Jul 30.
To date there have been no published studies of cognitive functioning in polycystic ovary syndrome (PCOS). This large internet-based study compared neuropsychological functioning in right-handed women with (minimum n=135) and without PCOS (minimum n=322), stratified according to use of anti-androgen medication and level of depression. Women with PCOS are thought to have hyperandrogenism and hyperestrogenism which was hypothesized to differentially influence cognitive function across cognitive domains. Performance did not differ according to diagnosis on mental rotation and spatial location tasks. Hence, no evidence to support the view that women with PCOS display a more masculine cognitive profile due to hyperandrogenism. Despite presumed hyperestrogenism, women with PCOS demonstrated impaired performance in terms of speed and accuracy, on reaction time and word recognition tasks. These findings are intriguing given the well-documented roles of estrogen and testosterone in cognitive function. Overall, these findings suggest that PCOS is not associated with masculinized cognitive functioning, and, although associated with impaired performance on tasks considered to demonstrate female-advantage, such impairments are subtle and are unlikely to affect daily functioning.
迄今为止，尚无关于多囊卵巢综合征（PCOS）认知功能的已发表研究。这项基于互联网的大型研究比较了使用抗雄激素药物和抑郁水平分层的、患有PCOS（最少n = 135）和未患PCOS（最少n = 322）的右利手女性的神经心理功能。患有PCOS的女性被认为具有高雄激素血症和高雌激素血症，据推测这会对不同认知领域的认知功能产生不同影响。在心理旋转和空间定位任务中，表现并未因诊断结果而有所不同。因此，没有证据支持患有PCOS的女性因高雄激素血症而表现出更具男性化认知特征的观点。尽管推测存在高雌激素血症，但患有PCOS的女性在反应时间和单词识别任务的速度和准确性方面表现受损。鉴于雌激素和睾酮在认知功能方面有充分记载的作用，这些发现很有趣。总体而言，这些发现表明PCOS与男性化认知功能无关，并且，尽管与被认为显示女性优势的任务表现受损有关，但这种损害很细微，不太可能影响日常功能。
