• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).

作者信息

Gebhardt P, Dornberger K, Gollmick F A, Gräfe U, Härtl A, Görls H, Schlegel B, Hertweck C

机构信息

Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, 07745 Jena, Germany.

出版信息

Bioorg Med Chem Lett. 2007 May 1;17(9):2558-60. doi: 10.1016/j.bmcl.2007.02.008. Epub 2007 Feb 7.

DOI:10.1016/j.bmcl.2007.02.008
PMID:17346963
Abstract

The fungus Daedalea quercina (oak mazegill) was examined for its capability of producing antioxidative and anti-inflammatory compounds. Bioactivity guided fractionation of the extract from a mycelial culture led to the isolation of quercinol, which was identified as (-)-(2S)-2-hydroxymethyl-2-methyl-6-hydroxychromene 1 by NMR and X-ray analyses. The cryptic hydroquinone 1 shows a broad anti-inflammatory activity against cyclooxygenase 2 (COX-2), xanthine oxidase (XO), and horseradish peroxidase (HRP) at micromolar concentrations.

摘要

相似文献

1
Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
Bioorg Med Chem Lett. 2007 May 1;17(9):2558-60. doi: 10.1016/j.bmcl.2007.02.008. Epub 2007 Feb 7.
2
Synthesis of 2-methyl-3-indolylacetic derivatives as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 without gastric damage.作为优先抑制环氧化酶1且无胃损伤的抗炎剂的2-甲基-3-吲哚基乙酸衍生物的合成。
J Med Chem. 2006 Dec 28;49(26):7774-80. doi: 10.1021/jm0608199.
3
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines.
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4597-601. doi: 10.1016/j.bmcl.2008.07.029. Epub 2008 Jul 15.
4
Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α.合成新型小檗因衍生物作为强效的炎症介质 NO 和 TNF-α 抑制剂。
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2744-7. doi: 10.1016/j.bmcl.2012.02.096. Epub 2012 Mar 3.
5
Rationalization of physico-chemical properties of 5, 6-diarylthiazolo [3,2-b]-1, 2, 4-triazoles towards cyclooxygenase-2 (COX-2) inhibition: a QSAR approach.5,6-二芳基噻唑并[3,2-b]-1,2,4-三唑对环氧合酶-2（COX-2）抑制作用的物理化学性质合理化：一种定量构效关系方法
Indian J Biochem Biophys. 2004 Aug;41(4):179-83.
6
On the antibiotic activity of oxazolomycin.
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4081-6. doi: 10.1016/j.bmcl.2008.05.105. Epub 2008 Jun 14.
7
Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors.来自桦褐孔菌属的异诺替龙及相关苯丙素聚酮化合物及其作为强效COX和XO抑制剂的鉴定。
Org Biomol Chem. 2006 Jul 7;4(13):2545-8. doi: 10.1039/b604505g. Epub 2006 May 24.
8
Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors.基于结构的平行药物化学方法提高苯并吡喃 COX-2 抑制剂的代谢稳定性。
Bioorg Med Chem Lett. 2011 Feb 1;21(3):993-6. doi: 10.1016/j.bmcl.2010.12.023. Epub 2010 Dec 10.
9
New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4655-7. doi: 10.1016/j.bmcl.2008.07.018. Epub 2008 Jul 10.
10
Synthesis and antimicrobial evaluation of some novel 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one.一些新型4-羟基色烯-2-酮的2-氨基噻唑衍生物的合成与抗菌活性评价
Arch Pharm (Weinheim). 2008 Aug;341(8):491-6. doi: 10.1002/ardp.200700215.

引用本文的文献

1
Antioxidant, Cytotoxic, and DNA Damage Protection Activities of Endophytic Fungus Isolated from Medicinal Plant.从药用植物中分离出的内生真菌的抗氧化、细胞毒性及DNA损伤保护活性
Microorganisms. 2023 Jan 1;11(1):117. doi: 10.3390/microorganisms11010117.
2
Loading of g-C N on Core-Shell Magnetic Mesoporous Silica Nanospheres as a Solid Base Catalyst for the Green Synthesis of some Chromene Derivatives under Different Conditions.将g-C₃N₄负载于核壳型磁性介孔二氧化硅纳米球上作为固体碱催化剂用于在不同条件下绿色合成某些色烯衍生物。
ChemistryOpen. 2022 Jul;11(7):e202200041. doi: 10.1002/open.202200041. Epub 2022 Jul 1.
3
Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications.
天然6-羟基色满醇和色烯醇：结构多样性、生物合成途径及对健康的影响
RSC Adv. 2018 Jan 26;8(9):4803-4841. doi: 10.1039/c7ra11819h. eCollection 2018 Jan 24.
4
Green Protocol for the Novel Synthesis of Thiochromeno[4,3-]pyridine and Chromeno[4,3-]pyridine Derivatives Utilizing a High-Pressure System.利用高压系统新型合成硫代色烯并[4,3 - ]吡啶和色烯并[4,3 - ]吡啶衍生物的绿色协议
ACS Omega. 2021 Nov 30;6(49):34065-34074. doi: 10.1021/acsomega.1c05347. eCollection 2021 Dec 14.
5
Punk's not dead. Fungi for tinder at the Neolithic site of La Draga (NE Iberia).朋克不死。在新石器时代的拉德拉加遗址（伊比利亚东北部）用真菌引火。
PLoS One. 2018 Apr 25;13(4):e0195846. doi: 10.1371/journal.pone.0195846. eCollection 2018.
6
An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions.在无催化剂条件下高效一锅法合成官能化色烯并[4,3 - b]吡啶衍生物。
Mol Divers. 2017 May;21(2):293-304. doi: 10.1007/s11030-016-9723-6. Epub 2017 Jan 31.
7
PubChem structure-activity relationship (SAR) clusters.美国国立医学图书馆化学数据库结构-活性关系（SAR）聚类
J Cheminform. 2015 Jul 7;7:33. doi: 10.1186/s13321-015-0070-x. eCollection 2015.
8
8-Meth-oxy-2H-chromene-3-carbaldehyde.8-甲氧基-2H-色烯-3-甲醛
Acta Crystallogr Sect E Struct Rep Online. 2012 Dec 1;68(Pt 12):o3419. doi: 10.1107/S1600536812047319. Epub 2012 Nov 24.