MMWR Morb Mortal Wkly Rep. 2007 Mar 9;56(9):193-6.
In 2005, approximately 8.9% (6.5 million) of U.S. children aged <18 years were reported to have current asthma. Children with asthma are at high risk for complications from influenza, and influenza vaccination has been determined to safely and effectively reduce rates of influenza in these children. Since its establishment in 1964, the Advisory Committee on Immunization Practices (ACIP) has recommended that all children with asthma aged > or =6 months receive vaccination with inactivated influenza vaccine during each influenza season; however, national influenza vaccination coverage rates specifically for children with asthma have not been determined. Previous studies have assessed influenza vaccination rates in children with asthma at the local level using health maintenance organization and clinician group-practice information, with estimates ranging from 10% to 43% for various influenza seasons. Another study used Behavioral Risk Factor Surveillance System (BRFSS) data to estimate influenza vaccination coverage in children aged 2-17 years with one or more conditions putting them at high risk for complications from influenza (including asthma, although asthma was not assessed separately); in that study, the national rate was estimated at 34.8% for the 2004-05 influenza season (based on a sample size of 685, which included all states and the District of Columbia [DC]). To estimate national influenza vaccination coverage rates among children aged 2-17 years with current asthma, CDC analyzed data from the 2005 National Health Interview Survey (NHIS). This report describes the results of that analysis and provides the first national estimates of influenza vaccination coverage among children with asthma. The findings indicated that although children with current asthma were more likely to receive influenza vaccination than children without current asthma, the vaccination coverage rate among children with asthma was low, at 29.0% (95% confidence interval [CI] = 24.5-33.9). These findings underscore the need to increase influenza vaccination coverage in children with asthma aged 2-17 years by identifying and overcoming barriers to vaccination.
2005年,据报告美国18岁以下儿童中约8.9%(650万)患有现患哮喘。哮喘患儿发生流感并发症的风险很高,并且已确定流感疫苗接种可安全有效地降低这些儿童的流感发病率。自1964年成立以来,免疫实践咨询委员会(ACIP)建议,每个流感季节,所有年龄≥6个月的哮喘患儿均接种灭活流感疫苗;然而,尚未确定哮喘患儿的全国流感疫苗接种覆盖率。以往的研究利用健康维护组织和临床医生团体执业信息在地方层面评估哮喘患儿的流感疫苗接种率,各流感季节的估计率在10%至43%之间。另一项研究利用行为危险因素监测系统(BRFSS)数据,估计2至17岁患有一种或多种使其发生流感并发症风险很高的疾病(包括哮喘,尽管未单独评估哮喘)的儿童的流感疫苗接种覆盖率;在该研究中,2004-2005年流感季节的全国接种率估计为34.8%(基于685人的样本量,包括所有州和哥伦比亚特区[DC])。为了估计2至17岁现患哮喘儿童的全国流感疫苗接种覆盖率,美国疾病控制与预防中心(CDC)分析了2005年全国健康访谈调查(NHIS)的数据。本报告描述了该分析结果,并首次提供了哮喘患儿流感疫苗接种覆盖率的全国估计数。结果表明,虽然现患哮喘的儿童比无现患哮喘的儿童更有可能接种流感疫苗,但哮喘患儿的疫苗接种覆盖率较低,为29.0%(95%置信区间[CI]=24.5-33.9)。这些结果强调,需要通过识别和克服疫苗接种障碍,提高2至17岁哮喘患儿的流感疫苗接种覆盖率。