Wickline Samuel A, Neubauer Anne M, Winter Patrick M, Caruthers Shelton D, Lanza Gregory M
Department of Medicine, Washington University, St. Louis, Missouri 63110, USA.
J Magn Reson Imaging. 2007 Apr;25(4):667-80. doi: 10.1002/jmri.20866.
Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.
在未来几十年里，生物纳米技术的进展有望对心血管诊断和治疗领域产生影响。本综述旨在举例说明一些新开发的诊断和治疗纳米系统，这些系统已在实验性动脉粥样硬化、血栓形成和血管生物学中得到评估。我们回顾了多种能够检测早期心血管病变的纳米技术，以及相关的成像方法和利用纳米颗粒递送系统进行靶向治疗的联合策略。
