Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Adv Healthc Mater. 2021 Mar;10(5):e2001044. doi: 10.1002/adhm.202001044. Epub 2020 Nov 23.
Recent advancements in unravelling elements of cancer biology involved in disease progression and treatment resistance have highlighted the need for a holistic approach to effectively tackle cancer. Stimuli-responsive nanotheranostics based on iron oxide nanoparticles are an emerging class of versatile nanomedicines with powerful capabilities to "seek, sense, and attack" multiple components of solid tumors. In this work, the rationale for using iron oxide nanoparticles and the basic physical principles that impact their function in biomedical applications are reviewed. Subsequently, recent advances in the integration of iron oxide nanoparticles with various stimulus mechanisms to facilitate the development of stimuli-responsive nanotheranostics for application in cancer therapy are summarized. The integration of an iron oxide core with various surface coating mechanisms results in the generation of hybrid nanoconstructs with capabilities to codeliver a wide variety of highly potent anticancer therapeutics and immune modulators. Finally, emerging future directions and considerations for their clinical translation are touched upon.
最近在揭示癌症生物学中与疾病进展和治疗耐药性相关的各个方面的进展，凸显了需要采用整体方法来有效治疗癌症。基于氧化铁纳米粒子的响应性纳米诊疗剂是一类新兴的多功能纳米药物，具有强大的“寻找、感知和攻击”实体瘤多个成分的能力。在这项工作中，我们回顾了使用氧化铁纳米粒子的基本原理，以及影响它们在生物医学应用中功能的基本物理原理。随后，总结了最近在将氧化铁纳米粒子与各种刺激机制集成以促进开发用于癌症治疗的响应性纳米诊疗剂方面的进展。将氧化铁核心与各种表面涂层机制集成，可产生具有递呈多种高效抗癌治疗剂和免疫调节剂的能力的混合纳米构建体。最后，还涉及到它们临床转化的新兴未来方向和考虑因素。
