Edling Charlotte E, Hallberg Bengt
Department of Medical Biosciences/Pathology, Build. 6M, Umeå University, S-901 87 Umeå, Sweden.
Int J Biochem Cell Biol. 2007;39(11):1995-8. doi: 10.1016/j.biocel.2006.12.005. Epub 2007 Jan 20.
The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for proliferation, survival and differentiation. During recent years exploration of the signalling pathways downstream of this receptor has yielded significant new insights in the field. In this review, we will summarise the c-Kit background, structure, downstream signalling and medical significance with particular focus on its role in hematopoietic progenitor cells and mast cells.
受体酪氨酸激酶c-Kit在造血干细胞和祖细胞以及几种非造血组织中表达。在造血系统中，c-Kit对增殖、存活和分化至关重要。近年来，对该受体下游信号通路的探索在该领域产生了重大的新见解。在这篇综述中，我们将总结c-Kit的背景、结构、下游信号传导和医学意义，特别关注其在造血祖细胞和肥大细胞中的作用。
