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唾液微囊泡增多与口腔鳞状细胞癌患者的预后相关。

Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma.

机构信息

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

出版信息

J Cell Mol Med. 2019 Jun;23(6):4054-4062. doi: 10.1111/jcmm.14291. Epub 2019 Mar 25.

DOI:10.1111/jcmm.14291
PMID:30907490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6533497/
Abstract

Microvesicles (MVs), which are cell-derived membrane vesicles present in body fluids, are closely associated with the development of malignant tumours. Saliva, one of the most versatile body fluids, is an important source of MVs. However, the association between salivary MVs (SMVs) and oral squamous cell carcinoma (OSCC), which is directly immersed in the salivary milieu, remains unclear. SMVs from 65 patients with OSCC, 21 patients with oral ulcer (OU), and 42 healthy donors were purified, quantified and analysed for their correlations with the clinicopathologic features and prognosis of OSCC patients. The results showed that the level of SMVs was significantly elevated in patients with OSCC compared to healthy donors and OU patients. Meanwhile, the level of SMVs showed close correlations with the lymph node status, and the clinical stage of OSCC patients. Additionally, the ratio of apoptotic to non-apoptotic SMVs was significantly decreased in OSCC patients with higher pathological grade. Consistently, poorer overall survival was observed in patients with lower ratio of apoptotic to non-apoptotic SMVs. In conclusion, the elevated level of SMVs is associated with clinicopathologic features and decreased survival in patients with OSCC, suggesting that SMVs are a potential biomarker and/or regulator of the malignant progression of OSCC.

摘要

微泡 (MVs) 是存在于体液中的细胞衍生的膜泡，与恶性肿瘤的发展密切相关。唾液是最具多功能的体液之一，是 MVs 的重要来源。然而，唾液来源的 MV（SMV）与直接浸润在唾液环境中的口腔鳞状细胞癌（OSCC）之间的关联尚不清楚。从 65 名 OSCC 患者、21 名口腔溃疡（OU）患者和 42 名健康供体中纯化、定量并分析了 SMVs，以研究其与 OSCC 患者的临床病理特征和预后的相关性。结果表明，与健康供体和 OU 患者相比，OSCC 患者的 SMV 水平显著升高。同时，SMV 水平与 OSCC 患者的淋巴结状态和临床分期密切相关。此外，在病理分级较高的 OSCC 患者中，凋亡型 SMV 与非凋亡型 SMV 的比例明显降低。一致的是，SMV 中凋亡型与非凋亡型的比例较低的患者总生存率较低。总之，SMV 水平的升高与 OSCC 患者的临床病理特征和生存率降低有关，表明 SMV 是 OSCC 恶性进展的潜在生物标志物和/或调节剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/e300638ce8f7/JCMM-23-4054-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/8ca64dc9c1d8/JCMM-23-4054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/2376ab0f9cd6/JCMM-23-4054-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/0930533e0479/JCMM-23-4054-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/e300638ce8f7/JCMM-23-4054-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/8ca64dc9c1d8/JCMM-23-4054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/2376ab0f9cd6/JCMM-23-4054-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/0930533e0479/JCMM-23-4054-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1024/6533497/e300638ce8f7/JCMM-23-4054-g004.jpg

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