Sallay K, Kulcsár G, Dán P, Nász I, Geck P
Dtsch Zahnarztl Z. 1975 Sep;30(9):570-5.
New results concerning the etiology of recurrent aphthae are reported. According to own experiments of the authors, adenoviruses persisting in the epithelial cells of the oral mucosa may sensitize the aphthous patient. Adenovirus antigen was demonstrable in the oral mucosa cells in more than 50% of the patients and in the lymphocytes in approx. 1% of the patients. Lymphoblast transformation in the circulating lymphocytes could be demonstrated in vitro with heat-inactivated type 1 adenovirus, in 75% of the patients. This virus type has been isolated from 2 patients. Köbner's isomorphous phenomenon could be demonstrated in aphthous patients. The use of a disinfectant for mouth rinsing, the removal of foci as well as vitamin treatment are recommended for preventing recurrent aphthae.
报告了有关复发性口疮病因的新结果。根据作者自身的实验，持续存在于口腔黏膜上皮细胞中的腺病毒可能使口疮患者致敏。在超过50%的患者口腔黏膜细胞以及约1%的患者淋巴细胞中可检测到腺病毒抗原。在体外，用热灭活的1型腺病毒可使75%的患者循环淋巴细胞发生淋巴细胞母细胞转化。已从2例患者中分离出这种病毒类型。在口疮患者中可证实有同形反应现象。建议使用消毒剂漱口、消除病灶以及进行维生素治疗以预防复发性口疮。
