Ongrádi J, Sallay K, Kulcsár G
Institute of Microbiology, Semmelweis University of Medicine, Budapest, Hungary.
Folia Microbiol (Praha). 1987;32(5):438-47. doi: 10.1007/BF02887577.
Patients suffering from periodontitis or periodontosis were selected for the study. Further subdivision of these groups was based on the presence or absence of herpes and/or adenoviruses in their oral lymphocytes and epithelial cells. The phagocytic and bactericidal activities of oral leukocytes isolated from the same individuals were compared with virus carriage. In the periodontitis group, 60.5%, and in the periodontosis group 61.5% of patients carried viruses, while this was established only in 21.1% of control cases. On the other hand, emigration and sulcular gathering of the less viable polymorphonuclear leukocytes was elevated but their phagocytotic activity was decreased among periodontitis patients. Bactericidal capacity was significantly lowered among those subjects who carried viruses in their cells, as compared with virus-free persons, especially in the periodontitis group. The functions of the polymorphonuclear leukocytes accumulated in the sulcus gingivalis may be modified by mediators released from the virus-carrying cells. These mediators could achieve a greater concentration locally, and the damaged leukocytes would not be able to eliminate the microbes continuously so that the accumulation of bacterial products, among them endotoxins, could lead to periodontal inflammation.
患有牙周炎或牙周病的患者被选入该研究。这些组别的进一步细分是基于其口腔淋巴细胞和上皮细胞中是否存在疱疹病毒和/或腺病毒。将从同一受试者分离出的口腔白细胞的吞噬和杀菌活性与病毒携带情况进行比较。在牙周炎组中，60.5%的患者携带病毒，在牙周病组中这一比例为61.5%，而在对照组中只有21.1%的患者携带病毒。另一方面，在牙周炎患者中，存活能力较低的多形核白细胞的游出和龈沟聚集增加，但其吞噬活性降低。与未携带病毒的人相比，细胞中携带病毒的受试者的杀菌能力显著降低，尤其是在牙周炎组。积聚在龈沟中的多形核白细胞的功能可能会被携带病毒的细胞释放的介质所改变。这些介质可能在局部达到更高的浓度，受损的白细胞将无法持续清除微生物，从而细菌产物（包括内毒素）的积累可能导致牙周炎症。
