Willén Carin, Thorén-Jönsson Anna-Lisa, Grimby Gunnar, Sunnerhagen Katharina Stibrant
Sahlgrenska Academy, Institute of Neurosciences and Physiology, Guldhedsgatan 19, Göteborg, Sweden.
J Rehabil Med. 2007 Mar;39(2):175-80. doi: 10.2340/16501977-0034.
To evaluate changes over time in a clinically based cohort of individuals with post-polio syndrome.
A prospective longitudinal study.
A total of 106 individuals with poliomyelitis sequelae were included in the study. They were self-referred or had been referred to the post-polio clinic. After 4 years subjects were called for a follow-up and underwent the same measurements as at the initial assessment.
The following measurements were conducted at both the initial assessment, and the follow-up: questionnaires including Nottingham Health Profile, muscle strength and walking speed.
Minor changes in disability during a 4-year period were shown. A significant reduction in muscle strength was only seen for 60 degrees flexion in the left leg and for right and left dorsal flexion. No change could be seen in the total Nottingham Health Profile score.
The minor changes in disability found in this study are an indication that we still do not know which subjects are at risk for deterioration. It is difficult to say whether the small changes over time shown in this study are associated with support from the polio clinic or are an expression of the natural history of the syndrome. However, it is hoped that support from the polio clinic may result in self-selected lifestyle changes, which may positively influence the development of symptoms and functional capacity.
评估小儿麻痹后遗症患者临床队列随时间的变化。
一项前瞻性纵向研究。
共有106例小儿麻痹后遗症患者纳入本研究。他们为自我转诊或被转诊至小儿麻痹后遗症诊所。4年后，对受试者进行随访，并进行与初始评估相同的测量。
在初始评估和随访时均进行以下测量：问卷调查，包括诺丁汉健康量表、肌肉力量和步行速度。
显示在4年期间残疾程度有轻微变化。仅左腿60度屈曲以及左右背屈时肌肉力量有显著下降。诺丁汉健康量表总分未见变化。
本研究中发现的残疾程度轻微变化表明，我们仍不清楚哪些受试者有病情恶化的风险。很难说本研究中随时间出现的微小变化是与小儿麻痹后遗症诊所的支持有关，还是该综合征自然病程的一种表现。然而，希望小儿麻痹后遗症诊所的支持可能会促使患者自主选择生活方式的改变，这可能对症状发展和功能能力产生积极影响。
