Skough Katarina, Krossén Charlott, Heiwe Susanne, Theorell Henning, Borg Kristian
Department of Clinical Sciences, Karolinska Institutet, Division of Rehabilitation Medicine, Danderyds Hospital, Stockolm, Sweden.
J Rehabil Med. 2008 Oct;40(9):773-5. doi: 10.2340/16501977-0245.
Coenzyme Q10 supplementation leads to increased muscle metabolism in patients with post-polio syndrome. The aim of this study was to investigate the effect of resistance training in combination with oral supplementation with coenzyme Q10 in patients with post-polio syndrome regarding muscle strength and endurance as well as functional capacity and health-related quality of life.
Parallel randomized, controlled, double-blind pilot study.
A total of 14 patients (8 women and 6 men) with post-polio syndrome participated in a 12-week muscular resistance training, 3 days/week. The patients were randomized for oral supplementation with coenzyme Q10, 200 mg/day, or placebo. Measurements used were: sit-stand-sit test, timed up & go test, 6-minute walk test, muscle strength measurement by means of dynamic dynamometer and short-form (SF)-36 questionnaire.
Muscle strength, muscle endurance and quality of life regarding mental health increased statistically significantly in all 14 patients. There was no significant difference between the coenzyme Q10 and placebo groups regarding muscle strength, muscle endurance and quality of life.
There was no effect of coenzyme Q10 supplementation during resistance training on post-polio syndrome symptoms. Thus, supplementation with coenzyme Q10 has no beneficial effect on muscle function in patients with post-polio syndrome.
补充辅酶Q10可使小儿麻痹后遗症患者的肌肉代谢增加。本研究旨在探讨抗阻训练联合口服辅酶Q10对小儿麻痹后遗症患者肌肉力量、耐力以及功能能力和健康相关生活质量的影响。
平行随机对照双盲试验性研究。
共有14例小儿麻痹后遗症患者（8例女性，6例男性）参与了为期12周的肌肉抗阻训练，每周3天。患者被随机分为口服辅酶Q10组（200毫克/天）或安慰剂组。所采用的测量指标包括：坐立试验、计时起立行走试验、6分钟步行试验、使用动态测力计测量肌肉力量以及简短健康调查问卷（SF-36）。
14例患者的肌肉力量、肌肉耐力以及心理健康方面的生活质量均有显著统计学提高。辅酶Q10组与安慰剂组在肌肉力量、肌肉耐力和生活质量方面无显著差异。
抗阻训练期间补充辅酶Q10对小儿麻痹后遗症症状无影响。因此，补充辅酶Q10对小儿麻痹后遗症患者的肌肉功能无有益作用。
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