大环野百合烷二萜类化合物作为抗肿瘤促长剂

Macrocyclic lathyrane diterpenes as antitumor promoters.

作者信息

Pusztai Rozália, Ferreira Maria-José U, Duarte Noélia, Engi Helga, Molnar Joseph

机构信息

Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.

出版信息

Anticancer Res. 2007 Jan-Feb;27(1A):201-5.

PMID:17352233

Abstract

Human cytomegalovirus (CMV) preferentially infects tumor tissues and the accumulated CMV immediate-early (IE) antigen may lead to tumor promotion and progression. The development of strategies to inhibit human CMV IE antigen expression and/or function is an important goal to prevent and treat certain forms of cancers associated with human CMV. The aim of this study was to search for antitumor promoters from plant sources. The effect of six macrocyclic lathyrane-type diterpenoids, latilagascenes A-E (1-5) and jolkinol B (6), isolated from the methanol extract of Euphorbia lagascae, on the expression of IE antigen in lung cancer cells (A549) infected by CMV was studied. All the compounds, except latilagascene D (4), decreased IE antigen expression of CMV.

摘要

人巨细胞病毒（CMV）优先感染肿瘤组织，积累的CMV即刻早期（IE）抗原可能导致肿瘤促进和进展。开发抑制人CMV IE抗原表达和/或功能的策略是预防和治疗某些与人类CMV相关癌症的重要目标。本研究的目的是从植物来源中寻找抗肿瘤促进剂。研究了从大戟属植物拉加斯卡大戟甲醇提取物中分离得到的六种大环拉替兰型二萜类化合物，即拉替拉加辛A-E（1-5）和jolkinol B（6），对CMV感染的肺癌细胞（A549）中IE抗原表达的影响。除拉替拉加辛D（4）外，所有化合物均降低了CMV的IE抗原表达。